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dc.contributor.authorJulian, Colleen Glyde
dc.contributor.authorVargas, Enrique
dc.contributor.authorGonzales, Marcelino
dc.contributor.authorDávila, R Daniela
dc.contributor.authorLadenburger, Anne
dc.contributor.authorReardon, Lindsay
dc.contributor.authorSchoo, Caroline
dc.contributor.authorPowers, Robert W
dc.contributor.authorLee-Chiong, Teofilo
dc.contributor.authorMoore, Lorna G
dc.date.accessioned2016-09-26T14:03:00Z
dc.date.available2016-09-26T14:03:00Z
dc.date.issued2013-01-22
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/8022
dc.description.abstractAbstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SBD) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2 patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18–25) with preclinical CMS ([excessive erythrocytosis (EE)], n=20) and controls (n=19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2 alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal SaO2, and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression.es_ES
dc.language.isoenes_ES
dc.publisherRespiratory Physiology & Neurobiologyes_ES
dc.subjectALTURAes_ES
dc.subjectESTRÉS OXIDATIVOes_ES
dc.subjectPOLICITEMIAes_ES
dc.titleSleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)es_ES
dc.typeArticlees_ES


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