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Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
dc.contributor.author | Julian, Colleen Glyde | |
dc.contributor.author | Vargas, Enrique | |
dc.contributor.author | Gonzales, Marcelino | |
dc.contributor.author | Dávila, R Daniela | |
dc.contributor.author | Ladenburger, Anne | |
dc.contributor.author | Reardon, Lindsay | |
dc.contributor.author | Schoo, Caroline | |
dc.contributor.author | Powers, Robert W | |
dc.contributor.author | Lee-Chiong, Teofilo | |
dc.contributor.author | Moore, Lorna G | |
dc.date.accessioned | 2016-09-26T14:03:00Z | |
dc.date.available | 2016-09-26T14:03:00Z | |
dc.date.issued | 2013-01-22 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/8022 | |
dc.description.abstract | Abstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SBD) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2 patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18–25) with preclinical CMS ([excessive erythrocytosis (EE)], n=20) and controls (n=19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2 alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal SaO2, and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Respiratory Physiology & Neurobiology | es_ES |
dc.subject | ALTURA | es_ES |
dc.subject | ESTRÉS OXIDATIVO | es_ES |
dc.subject | POLICITEMIA | es_ES |
dc.title | Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis) | es_ES |
dc.type | Article | es_ES |