• Login
    View Item 
    •   DSpace Home
    • Facultad de Medicina, Enfermería, Nutrición y Tecnología Médica
    • IBBA - Instituto Boliviano de Biología de la Altura
    • Producción científica
    • View Item
    •   DSpace Home
    • Facultad de Medicina, Enfermería, Nutrición y Tecnología Médica
    • IBBA - Instituto Boliviano de Biología de la Altura
    • Producción científica
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    The 70-kDa heat-shock protein is a major antigenic determinant in human Trypanosoma cruzi/Leishmania braziliensis braziliensis mixed infection

    Thumbnail
    View/Open
    LevyYeyati70-kDa.pdf (1.040Mb)
    Date
    1991
    Author
    Levy Yeyati, P
    Bonnefoy, S
    Mirkin, G
    Debrabant, A
    Lafon, S
    Panebra, A
    Gonzalez-Cappa, E
    Dedet, JP
    Hontebeyrie-Joskowicz, M
    Levin, MJ
    Metadata
    Show full item record
    Abstract
    Summary. Five sera from Bolivian individuals chronically infected by Trypanosoma cruzi, and suffering an active Leishmania braziliensis braziliensis metastasic mucocutaneous lesion were characterized. They reacted with the T. cruzi recombinant antigens that are currently used as Chagas disgnostic reagents, and with several L. b. braziliensis proteins as assessed by Western blot. These sera showed an intense reaction with a T. cruzi and a L. b. braziliensis polypeptide of about 70 kDa. Expression cloning techniques demonstrated that the target of this immunologic reaction was a cross-reactive antigen, the 70-kDa heat-shock protein (HSP 70). High levels of anti-HSP 70 reactivity and positive reactions with all or some of the T. cruzi recombinant antigens JL7, JL8, and JL5, defined a serologic pattern that was characteristic of the T. cruzi L. b. braziliensis mixed infection.
    URI
    http://repositorio.umsa.bo/xmlui/handle/123456789/22555
    Collections
    • Producción científica

    dsie
    Universidad Mayor de San Andrés
    Ciudad de La Paz - Estado Plurinacional de Bolivia
    copyleft © 2018 
    Contact Us | Send Feedback
    dsie
     

     


    dsie
    Universidad Mayor de San Andrés
    Ciudad de La Paz - Estado Plurinacional de Bolivia
    copyleft © 2018 
    Contact Us | Send Feedback
    dsie