Les chimanines, nouvelles quinoleines substituées en 2, isolées d'une plante bolivienne antiparasitaire: galipéa longiflora
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ABSTRACT.-Petroleum ether and CHCI₃, extracts of stem, root bark, and leaves of Galipea longifora were found active in vitro against Leishmania sp. and Trypanosoma cruzi at 100 µg/ml. The activity-guided fractionation of the extracts by chromatography afforded thirteen active compounds identified as 2-substituted quinoline alkaloids. Four new 2-alkylquinoline alkaloids were isolated and identified from leaves or trunk bark of G. longiflora: 4-methoxy-2-n-propylquinoline  (chimanine A), 2-(E)-prop-1 ‘-enylquinoline  (chimanine B), 4- methoxy-2-(E)-prop-1’-enylquinoline [12) (chimanine C), and 2-( 1 ’,2 ’-trans-epoxypropyl)- quinoline  (chimanine D). These alkaloids are accompanied by eight known 2-substituted quinolines (2-9), and by one known furo-(2,3b)-quinoline alkaIoid, skimmianine .