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dc.contributor.authorEsterre, P
dc.contributor.authorDedet, JP
dc.contributor.authorGuerret, S
dc.contributor.authorChevallier, M
dc.contributor.authorFrenay, C
dc.contributor.authorGrimaud, JA
dc.date.accessioned2017-09-08T12:53:17Z
dc.date.available2017-09-08T12:53:17Z
dc.date.issued1991
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/12398
dc.description.abstractSUMMARY. The connective matrix participates directly in early pathological events observed in the cutaneous lesion of leishmaniasis, due to Leishmania braziliensis guyanensis. A sample of 19 skin biopsies was examined by light and electron microscopy, in order to identify the matrix components (collagen isotypes I to lV, elastin and membrane associated proteins) of the dermal infiltrate, and the pattern of organization of the reparative connective matrix. An extensive remodelling process of apparently parasite-independent nature involves different fibroblast sub-populations. The original organization of this immune-mediated lesion offers a rare opportunity to study in situ the local inflammatory mediators inducing the activation of fibroblasts and macrophages.es_ES
dc.language.isoenes_ES
dc.publisherPath. Res. Pract.es_ES
dc.subjectMATRIZ DE REMODELACIÓNes_ES
dc.subjectLESIONES DE HUMANOSes_ES
dc.subjectLEISHMANIASIS CUTÁNEAes_ES
dc.titleMatrix remodelling and fibroblast phenotype in early lesions of human cutaneous Leishmaniasises_ES
dc.typeArticlees_ES


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