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Matrix remodelling and fibroblast phenotype in early lesions of human cutaneous Leishmaniasis
dc.contributor.author | Esterre, P | |
dc.contributor.author | Dedet, JP | |
dc.contributor.author | Guerret, S | |
dc.contributor.author | Chevallier, M | |
dc.contributor.author | Frenay, C | |
dc.contributor.author | Grimaud, JA | |
dc.date.accessioned | 2017-09-08T12:53:17Z | |
dc.date.available | 2017-09-08T12:53:17Z | |
dc.date.issued | 1991 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/12398 | |
dc.description.abstract | SUMMARY. The connective matrix participates directly in early pathological events observed in the cutaneous lesion of leishmaniasis, due to Leishmania braziliensis guyanensis. A sample of 19 skin biopsies was examined by light and electron microscopy, in order to identify the matrix components (collagen isotypes I to lV, elastin and membrane associated proteins) of the dermal infiltrate, and the pattern of organization of the reparative connective matrix. An extensive remodelling process of apparently parasite-independent nature involves different fibroblast sub-populations. The original organization of this immune-mediated lesion offers a rare opportunity to study in situ the local inflammatory mediators inducing the activation of fibroblasts and macrophages. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Path. Res. Pract. | es_ES |
dc.subject | MATRIZ DE REMODELACIÓN | es_ES |
dc.subject | LESIONES DE HUMANOS | es_ES |
dc.subject | LEISHMANIASIS CUTÁNEA | es_ES |
dc.title | Matrix remodelling and fibroblast phenotype in early lesions of human cutaneous Leishmaniasis | es_ES |
dc.type | Article | es_ES |