• Comparative responses of arterial oxygen saturation and heart rate durign postnatal development in rats living at high and low altitude 

      Lemoine, Alejandra Jochmans; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)
      We used pulse oximetry to measure arterial oxygen saturation (SpO2) and heart rate (HR) in 4 and 14 day-old rats raised at HA (La Paz, Bolivia, 3,600 m / 12,000ft) or at sea level (SL, Québec, Canada). SpO2 and HR were ...
    • Developmental components of resting ventilation among high - and low-altitude andean children and adults 

      Frisancho, A Roberto; Juliao, Patricia C; Barcelona, Verónica; Kudyba, Carmela E; Amayo, Glenda; Davenport, Grecia; Knowles, Alicia; Sánchez, Dani; Villena, Mercedes; Vargas, Enrique; Soria, Rudy (American Journal of Physical Anthroplogy, 1999)
      ABSTRACT. This paper evaluates the age-associated changes of resting ventilation of 115 high- and low-altitude Aymara subjects, of whom 61 were from the rural Aymara village of Ventilla situated at an average altitude ...
    • Developmental, genetic, and environmental components of aerobic capacity at high altitude 

      Frisancho, A Roberto; Frisancho, Hedy G; Milotich, Mark; Brutsaert, Tom; Albalak, Rachel; Spielvogel, Hilde; Villena, Mercedes; Vargas, Enrique; Soria, Rudy (American Journal of Physical Anthropology, 1995)
      Abstract. The aerobic capacity of 268 subjects (158 males and 110 females) was evaluated in La Paz, Bolivia situated at 3,750 m. The sample included 1) 39 high altitude rural natives (all male); 2) 67 high altitude urban ...
    • Divergent physiological responses in laboratory rats and mice raised at high altitude 

      Jochmans-Lemoine, Alejandra; Villalpando, Gabriela; Gonzales, Marcelino; Valverde, Ibana; Soria, Rudy; Joseph, Vincent (The Journal of Experimental Biology, 2015-01-29)
      Abstract. Ecological studies show that mice can be found at high altitude (HA – up to 4000 m) while rats are absent at these altitudes, and there are no data to explain this discrepancy. We used adult laboratory rats ...
    • Dopaminergic metabolism in carotid bodies and high altitude acclimatization in female rats 

      Joseph, Vincent; Soliz, Jorge; Soria, Rudy; Pequignot, Jacqueline; Favier, Roland; Spielvogel, Hilde; Pequignot, Jean Marc (Am J Physiol Relulatory, 2002-04)
      We tested the hypothesis that ovarian steroids stimulate breathing through a dopaminergic mechanism in the carotid bodies (CB). In ovariectomized female rats raised at sea level, domperidone, a peripheral D2 receptor ...
    • Effect of developmental and ancestral high-altitude exposure on chest morphology and pulmonary function in andean and european/north american natives 

      Brutsaert, Tom D; Soria, Rudy; Cáceres, Esperanza; Spielvogel, Hilde; Haas, Jere D (American Journal of Human Biology, 1999)
      Abstract. Chest depth, chest width, forced vital capacity (FVC), and forced expiratory volume (FEV1) were measured in 170 adult males differing by ancestral (genetic) and developmental exposure to high altitude (HA). A ...
    • Effect of developmental and ancestral high-altitude exposure on VO2peak of andean and european/north american natives 

      Brutsaert, Tom D; Spielvogel, Hilde; Soria, Rudy; Cáceres, Esperanza; Buzenet, Giliane; Haas, Jere D (American Journal of Physical Anthropology, 1999)
      ABSTRACT. Peak oxygen consumption (V02peak) was measured in 150 adult males (18-35 years old) in Bolivia, using a complete migrant study design to partition developmental from ancestral (genetic) effects of high altitude ...
    • Effects of prenatal hypoxia on hematological and respiratory acclimatization to high altitude in rats 

      Lemoine, Alejandra Jochmans; Lumbroso, Delphine; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)
      We tested the hypothesis that prenatal hypoxia have long-term consequences on physiological acclimatization to high altitude in rats. Male and female high-altitude rats (3600m, La Paz, Bolivia) were exposed to normal ...
    • Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude 

      Seaborn, Tommy; Gonzales, Marcelino; Villalpando, Gabriela; Grenacher, Beat; Soria, Rudy; Soliz, Jorge (Neuroscience Letters, 2011)
      Abstract. In addition to its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions against acute and delayed degenerative diseases of the brain. Moreover, we have recently demonstrated that ...
    • Graduated effects of high-altitude hypoxia and highland ancestry on birth size 

      Soria, Rudy; Julian, Colleen Glyde; Vargas, Enrique; Moore, Lorna G; Giussani, Dino A (Pediatric Research, 2013-10-02)
      Background: We present a cohort of ca. 25,000 birth records from Bolivia of men and women who are currently adults. We used this cohort to test the hypothesis that high altitude reduces birth weight and that highland ...
    • Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara 

      Beall, Cynthia M; Brittenham, Gary M; Strohl, Kingman P; Blangero, John; Williams-Blanguero, Sarah; Goldstein, Melvyn C; Decker, Michael J; Vargas, Enrique; Villena, Mercedes; Soria, Rudy; Alarcón, Ana María; Gonzales, Cristina (American Journal of Physical Anthropology, 1998)
      Abstract. Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing ...
    • Hemoglobin mass and blood volume in patients with altitude-related polycythemia 

      Schmidt, Walter FJ; Wachsmuth, Nadine; Jiménez, Jesús; Soria, Rudy (Frontiers in Physiology, 2022)
      Patients with chronic mountain sickness (CMS) have a high hemoglobin concentration [Hb] due to increased hemoglobin mass (Hbmass) and possibly reduced plasma volume (PV). The values of Hbmass, PV and blood volume (BV) have ...
    • Higher arterial oxygen saturation during submaximal exercise in bolivian aymara compared to european sojourners and europeans born and raised at high altitude 

      Brutsaert, Tom D; Araoz, Mauricio; Soria, Rudy; Spielvogel, Hilde; Haas, Jere D (American Journal of Physical Anthropology, 2000)
      Abstract. Arterial oxygen saturation (SaO(2)) was measured at 3,600-3,850 m by pulse oximetry at rest and during submaximal exercise in three study groups: 1) highland Aymara natives of the Bolivian altiplano (n = 25); ...
    • Methods of the international study on soccer at altitude 3600 m (ISA 3600) 

      Gore, Christopher J; Aughey, Robert J; Bourdon, Pitre C; Garvican-Lewis, Laura A; Soria, Rudy; Jiménez Claros, Jesús C; Sangent, Charli; Roach, Gregory D; Buchheit, Martin; Simpson, Ben M; Hammond, Kristal; Kley, Marlen; Wachsmuth, Nadine; Pepper, Mark; Edwards, Alistair; Cuenca, Douglas; Vidmar, Tony; Spielvogel, Hilde; Schmidt, Walter F (Br J Sports Med, 2013-07-10)
      Abstract. Background: We describe here the 3-year process underpinning a multinational collaboration to investigate soccer played at high altitude—La Paz, Bolivia (3600 m). There were two main aims: first, to quantify the ...
    • Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m 

      Beall, Cynthia M; Almasy, Laura A; Blangero, John; Williams-Blangero, Sarah; Brittenham, Gary M; Strohl, Kingman P; Decker, Michael J; Vargas, Enrique; Villena, Mercedes; Soria, Rudy; Alarcón, Ana María; Gonzales, Cristina (American Journal of Physical Anthroplogy, 1999)
      ABSTRACT. A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient ...
    • Permormance of altitude acclimatized and non-acclimatized professional football (soccer) players at 3,600 M 

      Brutsaert, Tom D; Spielvogel, Hilde; Soria, Rudy; Araoz, Mauricio; Cáceres, Esperanza; Buzenet, Giliane; Villena, Mercedes; Paz-Zamora, Mario; Vargas, Enrique (Journal of Exercise Physiology, 2000-04-02)
      European football (soccer) matches frequently are played at the international level in mountainous regions of South America. In this study, the exercise response during cycle ergometry and the rate of football match ...
    • Plasma antioxidant capacity in highland subjects exposed at 5200 meters of altitude 

      Negrón Arroyo, Claudia C; Peredo Núñez de Arco, Rossana K; Fernández Pinto, J. Víctor; Fuentes Zenteno, Catalina S; Bravo, José A; Alvarado, Juan Antonio; Soria, Rudy; Peñarrieta, J. Mauricio (Revista Boliviana de Química, 2014-06-30)
      Abstract. Human exposure to high altitude conditions (reduced barometric pressure) leads to the formation of free radicals, which could be a major cause of altitude sickness. In the present study the total antioxidant ...
    • Predicting sickness during a 2-week soccer camp at 3600 m (ISA 3600) 

      Buchheit, Martin; Simpson, Ben M; Schmidt, Walter F; Aughey, Robert J; Soria, Rudy; Hunt, Robert A; Garvican-Lewis, Laura A; Pyne, David B; Gore, Christopher J; Bourdon, Pitre C (Br J Sports Med, 2013-08-23)
      Abstract. Objectives. To examine the time course of changes in wellness and health status markers before and after episodes of sickness in young soccer players during a high-altitude training camp (La Paz, 3600 ...
    • Programmation prénatale de l'acclimatation hématologique et respiratoire chez des rats de haute altitude 

      Lemoine, Alejandra Jochmans; Lumbroso, Delphine; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)
      Nous avons testé l’hypothèse selon laquelle l’hypoxie prénatale chez le rat aurait des conséquences à long terme sur l’acclimatation physiologique à la haute altitude. Des rats vivant en haute altitude (3600m, La Paz, ...
    • Pulmonary nitric oxide in mountain dwellers 

      Beall, Cynthia M; Laskowski, Daniel; Strohl, Kingman; Soria, Rudy; Villena, Mercedes; Vargas, Enrique; Alarcón, Ana María; Gonzales, Cristina; Erzurum, Serpil C (NATURE, 2001-11-22)
      Nitric oxide is synthesized in the lungs to help regulate blood flow, and its levels have been found to drop in species native to low altitudes, including humans, upon acute exposure to reduced oxygen concentration1–3. ...