Percent of oxygen saturation of arterial hemoglobin among Bolivian aymara at 3,900-4000 m
Fecha
1999Autor
Beall, Cynthia M
Almasy, Laura A
Blangero, John
Williams-Blangero, Sarah
Brittenham, Gary M
Strohl, Kingman P
Decker, Michael J
Vargas, Enrique
Villena, Mercedes
Soria, Rudy
Alarcón, Ana María
Gonzales, Cristina
Metadatos
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ABSTRACT.
A range of variation in percent of oxygen saturation of
arterial hemoglobin (SaO2) among healthy individuals at a given high
altitude indicates differences in physiological hypoxemia despite uniform
ambient hypoxic stress. In populations native to the Tibetan plateau, a
significant portion of the variance is attributable to additive genetic factors,
and there is a major gene influencing SaO2. To determine whether there is
genetic variance in other high-altitude populations, we designed a study to
test the hypothesis that additive genetic factors contribute to phenotypic
variation in SaO2 among Aymara natives of the Andean plateau, a population
geographically distant from the Tibetan plateau and with a long, separate
history of high-altitude residence. The average SaO2 of 381 Aymara at
3,900–4,000 m was 92 6 0.15% (SEM) with a range of 84–99%. The average
was 2.6% higher than the average SaO2 of a sample of Tibetans at 3,800–4,065
m measured with the same techniques. Quantitative genetic analyses of the
Aymara sample detected no significant variance attributable to genetic
factors. The presence of genetic variance in SaO2 in the Tibetan sample and its
absence in the Aymara sample indicate there is potential for natural selection
on this trait in the Tibetan but not the Aymara population. Am J Phys
Anthropol 108:41–51, 1999.