• Permormance of altitude acclimatized and non-acclimatized professional football (soccer) players at 3,600 M 

      Brutsaert, Tom D; Spielvogel, Hilde; Soria, Rudy; Araoz, Mauricio; Cáceres, Esperanza; Buzenet, Giliane; Villena, Mercedes; Paz-Zamora, Mario; Vargas, Enrique (Journal of Exercise Physiology, 2000-04-02)
      European football (soccer) matches frequently are played at the international level in mountainous regions of South America. In this study, the exercise response during cycle ergometry and the rate of football match ...
    • La pletismografía como método de apoyo diagnóstico en las enfermedades broncopulmonares en nuestro medio 

      Villena, Mercedes; Vargas, Enrique; Videa G., Ricardo (Instituto Boliviano de Biología de Altura, 1983)
      Resumen. Se trata de una comunicación preliminar de un estudio que tiene por finalidad establecer, por pletismografía corporal total, parámetros normales de la función respiratoria en personas habitantes de altura (3.600 ...
    • Poliglobulia patológica de altura, diversidad clínica y exámenes complementarios 

      Aparicio, Octavio; Antezana, Gerardo; Vargas, Enrique; Villena, Mercedes (Universidad Mayor de San Andrés, 1990)
      Abstract. Clinical and laboratory findings of 42 patients with High Altitude Polycythemia were analyzed consecutively. All patients had hemoglobin (Hb) and hematocrit (Ht) levels above 19 g/dl and 60%, respectively. Patients ...
    • Poliglobulia y ejercicio muscular 

      Spielvogel, Hilde; Vargas, Enrique; Paz Zamora, Mario; Haas, Jere; Beard, John L; Tufts, Gillian; Cudkowicz, León (Gaceta del Tórax, 1981)
    • Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA 

      Julian, Colleen Glyde; Vargas, Enrique; Browne, Vaughn A.; Wilson, Megan J; Bigham, Abigail W; Rodríguez, Carmelo; McCord, Joe M; Moore, Lorna G (The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
      Oxidative stress has been implicated in the uteroplacental ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high (>2500 m) vs low altitude. Since Andeans ...
    • Protective effect of female sex hormones against pulmonary hypertension in Bolivian high altitude natives 

      Sartori, Claudio; Allemann, Yves; Salinas Salmón, Carlos E; Turini, Pierre; Rodríguez, Armando; Hutter, Damián; Thalmann, Sébastien; Vargas, Enrique; Villena, Mercedes; Scherrer, Urs (High Altitude Medicine & Biology, 2003-02-19)
      There is abundant evidence that female sex hormones have protective effects in the systemic circulation in both animals and humans, but little is known regarding their role in the regulation of the pulmonary circulation. ...
    • Pulmonary diffusing capacity in young andean highland children 

      Vargas, Enrique; Beard, John; Haas, Jere; Cudkowicz, Leon (Respiration, 1982)
      Abstract. Lung diffusing capacities for carbon monoxide were measured in 125 highland Andean children between 4 and 6 years of age in La Paz, Bolivia (3,650 m), using a steady-state technique. Male children had a significantly ...
    • Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution 

      Manier, Gérard; Guenard, Hervé; Castaing, Yves; Varene, Nicole; Vargas, Enrique (J. Appl. Physiol., 1988)
      Pulmonary gas exchange in andean natives (n =8) with excessive high-altitude (3,600-4,200 m) polycythemia (hematocrit 65.1 +- 6.6%) and hipoxemia (arterial PO2 45.6+-5.6 Torr) in the absence of pulmonary or cardiovascular ...
    • Pulmonary nitric oxide in mountain dwellers 

      Beall, Cynthia M; Laskowski, Daniel; Strohl, Kingman; Soria, Rudy; Villena, Mercedes; Vargas, Enrique; Alarcón, Ana María; Gonzales, Cristina; Erzurum, Serpil C (NATURE, 2001-11-22)
      Nitric oxide is synthesized in the lungs to help regulate blood flow, and its levels have been found to drop in species native to low altitudes, including humans, upon acute exposure to reduced oxygen concentration1–3. ...
    • Reduced endothelin-1 (ET-1) and elevated nitric oxide metabolites (NOX) across pregnancy among andean vs. european women at high (3100-3600 m) altitude 

      Julian, Colleen Glyde; Wilson, Megan; Vargas, Enrique; Vargas, Marco; López, Miriam; Niermeyer, Susan; Moore, Lorna G (High Altitude Medicine & Biology, 2005-02-22)
      Background. A consistent reduction in infant birth weight occurs with ascending altitude; however multigenerational high-altitude residents [Andeans] demonstrate a degree of protection from altitude-associated IUGR ...
    • Rendimiento de futbolistas profesionales aclimatados y no aclimatados a la altura, a 3600 metros 

      Brutsaert, Tom D; Spielvogel, Hilde; Soria, Rudy; Araoz, Mauricio; Cáceres, Esperanza; Buzenet, Giliane; Villena, Mercedes; Paz-Zamora, Mariano; Vargas, Enrique (PubliCE, 2003-01-05)
      Resumen. Los partidos del Fútbol Europeo son frecuentemente jugados a nivel internacional en regiones montañosas de Sudamérica. En este estudio, fueron medidas las respuestas del ejercicio durante una ergometría en ciclo ...
    • Repercuciones cardiorespiratorias del uso de una mascara antipolvo durante el esfuerzo muscular en la altura. La Paz 3.600 Mts. 

      Vargas, Enrique; Antezana, Gerardo; Coudert, Jean; Thorn, Anette; Haftel, Willy (Instituto Boliviano de Biología de Altura, 1979)
      Es bien conocido actualmente que el ejercicio muscular en la altura se realiza en condiciones diferentes de las del nivel del mar: la capacidad aeróbica máxima se encuentra disminuida, para ejercicio submáximo de la misma ...
    • Role of cytokines in altitude-associated preeclampsia 

      Dávila, R Daniela; Julian, Colleen Glyde; Browne, Vaughn A.; Toledo-Jaldín, Lillian; Wilson, Megan J; Rodríguez, Armando; Vargas, Enrique; Moore, Lorna G (Pregnancy Hypertens, 2012-01)
      Abstract. Background: Preeclampsia (PE) is more common at high than low altitude and contributes to the altitude-related decline in birth weight. Since inflammatory markers are implicated in PE, we asked if such markers ...
    • Role of genetic and environmental factors in the increased blood pressures of Bolivian blacks 

      Frisancho, A Roberto; Farrow, S; Friedenzohn, Isabel; Johnson, Tiffany; Kapp, Beth; Miranda, Christina; Pérez, María; Rauchle, Isha; Sánchez, Nicholas; Wheatcroft, Gloria; Woodill, Lita; Ayllón, Irma; Bellido, Diva; Rodríguez, Armando; Machicao, Jorge; Villena, Mercedes; Vargas, Enrique (American Journal of Human Biology, 1999)
      Abstract. The tendency toward hypertension or higher blood pressure is more common in blacks than whites. The factors that account for these differences are attributed to both environmental and genetic factors. To clarify ...
    • Seasonal and circadian variation in salivary testosterone in rural Bolivian men 

      Vitzthum, Virginia J; Worthman, Carol M; Beall, Cynthia M; Thornburg, Jonathan; Vargas, Enrique; Villena, Mercedes; Soria Sánchez, Rudy; Cáceres, Esperanza; Spielvogel, Hilde (American Journal of Human Biology, 2009-02-19)
      Abstract. Testosterone (T) plays a key role in the increase and maintenance of muscle mass and bone density in adult men. Life history theory predicts that environmental stress may prompt a reallocation of such investments ...
    • Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis) 

      Julian, Colleen Glyde; Vargas, Enrique; Gonzales, Marcelino; Dávila, R Daniela; Ladenburger, Anne; Reardon, Lindsay; Schoo, Caroline; Powers, Robert W; Lee-Chiong, Teofilo; Moore, Lorna G (Respiratory Physiology & Neurobiology, 2013-01-22)
      Abstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores ...
    • The effects of smoking on a high altitude population. (La Paz, Bolivia, 3600m or 12,200ft) 

      Spielvogel, Hilde; Aparicio, Octavio; Bellido, Diva; Galarza, Mario; Nallar, Nancy; Quintela, Aida; Peñaloza, Rosario; Tellez, Wilma; Vargas, Enrique; Villena, Mercedes (Tobacco and Health, 1990)
      Barometric pressure (PB) decreases with increasing a altitude. Since oxygen concentration is about 21% in the air of the whole atmosphere, its partial pressure is also 21% of PB. At the altitude of La Paz (3600)m or ...
    • The relationship between perinatl hypoxia and sleep-disordered breathing in preclinical chronic mountain sickness 

      Julian, Colleen Glyde; Vargas, Enrique; Dávila, R Daniela; Salinas Salmón, Carlos E; Rodríguez, A; Gonzales, Marcelino; Moore, Lorna G (High Altitude Medicine & Biology, 2010-08-08)
      Introduction: Chronic intermittent hypoxia due to sleepdisordered breathing is implicated as a potential etiological factor for chronic mountain sickness (CMS). Whether sleepdisordered breathing precedes or results from ...
    • The role of perinatal hypoxia in the development of preclinical CMS 

      Vargas, Enrique (High Altitude Medicine & Biology, 2010-08-08)
    • Transporte de oxígeno y hematología en niños de altura 

      Beard, Jhon L; Hurtado, Luis; Villena, Mercedes; Vargas, Enrique (Instituto Boliviano de Biología de Altura, 1979)
      Summary. 34 healthy children in the middle of the important growth and development years, 2-7 years, were examined for effective oxygen transport and hematological parameters as a function of residing at either 3.600 m. ...