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Protective effect of female sex hormones against pulmonary hypertension in Bolivian high altitude natives
(High Altitude Medicine & Biology, 2003-02-19)
There is abundant evidence that female sex hormones have protective effects in the systemic circulation in both animals and humans,
but little is known regarding their role in the regulation of the pulmonary circulation. ...
Uterine artery blood flow during pregnancy in high-altitude aymara women
(High Altitude Medicine & Biology, 2003-02-19)
Background.
Birth weight falls with increasing altitude as the result of
intrauterine growth restriction (IUGR) likely due, in turn, to lower uterine artery (UtA) blood flow. The altitude-associated birth weight decline
is ...
Excessive polycythemia occurs in young high-altitude (3600 M) residents in the absence of lung disease
(High Altitude Medicine & Biology, 2002-04-18)
Objective: Chronic Mountain Sickness occurs in , 8% of the La Paz
population. We asked whether its primary diagnostic sign, excessive polycythemia (EP), occurred in youngeraged persons
without lung disease. Methods: ...
Postnatal changes in the pulmonary circulation at 3700-4000 m
(High Altitude Medicine & Hygiene, 2002-04-18)
Objective: The hypoxia of high altitude can impair
postnatal changes in the pulmonary circulation. We documented pulmonary artery pressures (PPA) and persistence of fetal circulatory patterns among infants born at
3700–4000m ...
Reduced endothelin-1 (ET-1) and elevated nitric oxide metabolites (NOX) across pregnancy among andean vs. european women at high (3100-3600 m) altitude
(High Altitude Medicine & Biology, 2005-02-22)
Background.
A consistent reduction in infant birth
weight occurs with ascending altitude; however multigenerational high-altitude residents [Andeans] demonstrate a degree of protection from altitude-associated
IUGR ...
Aymara children are protected from high-altitude-induced pulmonary hypertension
(High Altitude Medicine & Biology, 2005-02-22)
Pulmonary hypertension is a hallmark of the adaptation to ambient lack of oxygen. This assumption is also
thought to hold true for high-altitude native children,
since invasive studies showed elevated pulmonary-artery
pressure ...
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
(High Altitude Medicine & Biology, 2005-02-22)
Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors
that cause maternal endothelial dysfunction. These factors ...
Epidemiological transitions, reproductive health, and the Flexible Response Model
(ECONOMICS AND HUMAN BIOLOGY, 2003)
Abstract.
In concert with improving standards of living since the mid-19th century, chronic and non-infectious diseases replaced infectious diseases as the major causes of mortality in more developed countries. Thus, ...
European genetic admixture predicts decrement in aerobic performance at 4338 meters in peruvian quechua
(High Altitude Medicine & Biology, 2003-02-19)
Quechua natives of the highland Andes may be genetically
adapted to high altitude and thus able to resist decrements in maximal O2 consumption in hypoxia (DVO2max). This evolutionary hypothesis was tested via the repeated ...
Where the O2 goes to : preservation of human fetal oxygen delivery and consumption at high altitude
(The Journal of Physiology, 2009)
Fetal growth is decreased at high altitude (> 2700 m). We hypothesized that variation in fetal O2
delivery might account for both the altitude effect and the relative preservation of fetal growth in
multigenerational ...