Listar Producción científica por autor "Rodríguez, Carmelo"
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Andean and Tibetan patterns of adaptation to high altitude
Bigham, Abigail W; Wilson, Megan J; Julian, Colleen Glyde; Kiyamu, Melisa; Vargas, Enrique; León-Velarde, Fabiola; Rivera-Chira, María; Rodríguez, Carmelo; Browne, Vaughn A.; Parra, Esteban; Brutsaert, Tom D; Moore, Lorna G; Shriver, Mark D (American Journal of Human Biology, 2013-01-24)Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ... -
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
Julian, Colleen Glyde; Wilson, Megan J; López, Miriam; Yamashiro, Henry; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail W; Shriver, Mark D; Rodríguez, Carmelo; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2009-02-20)Abstract. The effect of high altitude on reducing birth weight is markedly less in populations of high- (e.g., Andeans) relative to low-altitude origin (e.g., Europeans). Uterine artery (UA) blood flow is greater ... -
Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A.; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reprod Sci., 2010-09)Abstract. Objective: This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors contribute ... -
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reproductive Sciences, 2011)Abstract. Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ... -
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
Julian, Colleen Glyde; Yang, Ivana V; Browne, Vaughn A.; Vargas, Enrique; Rodríguez, Carmelo; Pedersen, Brent S; Moore, Lorna G; Schwartz, David A (FASEB Journal, 2014)Abstract. Chronic exposure to hypoxia raises the risk of pregnancy disorders characterized by maternal vascular dysfunction and diminished fetal growth. In an effort to identify novel pathways for these hypoxiarelated ... -
Índice de resistencia vascular arterial en la madre y el feto durante el embarazo en grandes alturas (3600 m) vs. niveles bajos de altura (300 m)
Postigo, Lucrecia; Heredia, Gladis; Rodríguez, Carmelo; Toledo, Lilian; Torricos, Tatiana; Vargas, Enrique; Zamudio, Stacy (Revista de la Sociedad Boliviana de Radiología, 2007)Resumen. Objetivo: Determinar los índices de resistencia de las arterias uterinas en las madres, umbilical y cerebral media en los bebés de grandes alturas, en comparación a pacientes que habitan alturas bajas reflejados ... -
Maternal oxygen delivery is not related to altitude- and ancestry-associated differences in human fetal growth
Zamudio, Stacy; Postigo, Lucrecia; Illsley, Nicholas P; Rodríguez, Carmelo; Heredia, Gladys; Brimacombe, Michael; Echalar, Lourdes; Torricos, Tatiana; Téllez, Wilma; Maldonado, Iván; Balanza Erquicia, Elfride; Álvarez, Tatiana; Ameller, Julio; Vargas, Enrique (J Physiol, 2007-09-16)Fetal growth is reduced at high altitude, but the decrease is less among long-resident populations. We hypothesized that greater maternal uteroplacental O2 delivery would explain increased fetal growth in Andean natives ... -
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
Julian, Colleen Glyde; Vargas, Enrique; Browne, Vaughn A.; Wilson, Megan J; Bigham, Abigail W; Rodríguez, Carmelo; McCord, Joe M; Moore, Lorna G (The Journal of Maternal-Fetal and Neonatal Medicine, 2012)Oxidative stress has been implicated in the uteroplacental ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high (>2500 m) vs low altitude. Since Andeans ...