Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
Fecha
2011Autor
Dávila, R Daniela
Julian, Colleen Glyde
Wilson, Megan J
Browne, Vaughn A
Rodríguez, Carmelo
Bigham, Abigail W
Shriver, Mark D
Vargas, Enrique
Moore, Lorna G
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Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean (AND) versus shorter duration European (EUR) high-altitude (HA) residents are protected from altitude-associated FGR. To address whether ancestry group differences in cytokine levels were involved, we conducted serial studies in 56 low-altitude ([LA]; 400 m; n ¼ 29 AND and n ¼ 27 EUR) and 42
HA residents (3600-4100 m; n ¼ 19 ANDs and n ¼ 23 EURs). Pregnancy raised pro- (interleukin 1b [IL-1b]) and anti- (IL-10)
inflammatory cytokines and HA lowered IL-6 and tumor necrosis factor-a (TNF-a) near term. There were no ancestry group
differences in cytokine levels at any time, but HA reduced IL-1b in ANDs only near term. Higher IL-1b levels correlated with
uterine artery (UA) blood flow at 20 weeks in ANDs at HA, suggesting that IL-1b may play a role in AND protection from
altitude-associated reductions in fetal growth.