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Evidence for extraplacental sources of circulating angiogenic growth effectors in human pregnancy
(Placenta, 2013-08-24)
Abastract.
Pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are
associated with reduced blood flow, contributing to placental and fetal hypoxia. Placental hypoxia is
thought ...
Role of cytokines in altitude-associated preeclampsia
(Pregnancy Hypertens, 2012-01)
Abstract.
Background: Preeclampsia (PE) is more common at high than low altitude and contributes
to the altitude-related decline in birth weight. Since inflammatory markers are implicated
in PE, we asked if such markers ...
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Climate change and global health : a Latin American perspective
(CAB International, 2014)
Abstract:
The epidemiological profile of Latin America (LA) is marked by diseases of poverty and underdevelopment. Climate change is also reinforcing the intensity and frequency of climate variability, with more intense ...
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
(American Journal of Human Biology, 2011-04-27)
Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important
determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ...
Unique DNA methylation patterns in offspring of hypertensive pregnancy
(Clin Transl Sci., 2015)
Abstract.
Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...
Ancient human genomes suggest three ancestral populations for present-day Europeans
(Nature, 2014-09-18)
We sequenced the genomes of a 7,000-year-old farmer from Germanyandeight 8,000-year-oldhunter-gatherersfromLuxembourg and Sweden. We analysed these and other ancient genomes1–4 with 2,345contemporaryhumanstoshowthatmostp ...
Climate change and health vulnerability in Bolivian Chaco ecosystems
(Springer, 2016-03-25)
Abstract.
Climate change and variability is impacting health, across different spatial scales, ecosystems, and water supply and quality. In Bolivia climate change is operating in a framework of poverty and inequality. ...
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...
mtDNA and y-chromosome diversity in aymaras and quechuas from Bolivia : different stories and special genetic traits of the andean altiplano populations
(American Journal of Physical Anthroplogy, 2011-04-05)
Abstract.
Two Bolivian samples belonging to the
two main Andean linguistic groups (Aymaras and Quechuas) were studied for mtDNA and Y-chromosome uniparental markers to evaluate sex-specific differences and
give new ...