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Reduced endothelin-1 (ET-1) and elevated nitric oxide metabolites (NOX) across pregnancy among andean vs. european women at high (3100-3600 m) altitude
(High Altitude Medicine & Biology, 2005-02-22)
Background.
A consistent reduction in infant birth
weight occurs with ascending altitude; however multigenerational high-altitude residents [Andeans] demonstrate a degree of protection from altitude-associated
IUGR ...
High-altitude ancestry protects against hypoxia-associated reductions in fetal growth
(Archives of Disease in Childhood-Fetal and Neonatal, 2007-02-28)
Objective: The chronic hypoxia of high-altitude (>2500 m) residence has been shown to decrease birth
weight in all populations studied to date. However, multigenerational high-altitude populations appear
protected relative ...
Andean and Tibetan patterns of adaptation to high altitude
(American Journal of Human Biology, 2013-01-24)
Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the
ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
(Am J Physiol Regul Integr Comp Physiol, 2011)
The reduction in
infant birth weight and increased frequency of preeclampsia (PE) in
high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
(Reproductive Sciences, 2011)
Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...
Role of cytokines in altitude-associated preeclampsia
(Pregnancy Hypertens, 2012-01)
Abstract.
Background: Preeclampsia (PE) is more common at high than low altitude and contributes
to the altitude-related decline in birth weight. Since inflammatory markers are implicated
in PE, we asked if such markers ...
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
(American Journal of Human Biology, 2011-04-27)
Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important
determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ...
Unique DNA methylation patterns in offspring of hypertensive pregnancy
(Clin Transl Sci., 2015)
Abstract.
Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
(Am J Physiol Regul Integr Comp Physiol, 2009-02-20)
Abstract.
The effect of high altitude on reducing birth weight is markedly less in
populations of high- (e.g., Andeans) relative to low-altitude origin
(e.g., Europeans). Uterine artery (UA) blood flow is greater ...