Listar Producción científica por autor "Shriver, Mark D"

Mostrando ítems 1-7 de 7

    • A genomewide admixture mapping panel for hispanic/latino populations 

      Xianyun, Mao; Bigham, Abigail W; Mei, Rui; Gutiérrez, Gerardo; Weiss, Ken M; Brutsaert, Tom D; León-Velarde, Fabiola; Moore, Lorna G; Vargas, Enrique; McKeigue, Paul M; Shriver, Mark D; Parra, Esteban J (The American Journal of Human Genetics, 2007-06)
      Admixture mapping (AM) is a promising method for the identification of genetic risk factors for complex traits and diseases showing prevalence differences among populations. Efficient application of this method requires the ...

    • Andean and Tibetan patterns of adaptation to high altitude 

      Bigham, Abigail W; Wilson, Megan J; Julian, Colleen Glyde; Kiyamu, Melisa; Vargas, Enrique; León-Velarde, Fabiola; Rivera-Chira, María; Rodríguez, Carmelo; Browne, Vaughn A.; Parra, Esteban; Brutsaert, Tom D; Moore, Lorna G; Shriver, Mark D (American Journal of Human Biology, 2013-01-24)
      Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...

    • Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth 

      Julian, Colleen Glyde; Wilson, Megan J; López, Miriam; Yamashiro, Henry; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail W; Shriver, Mark D; Rodríguez, Carmelo; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2009-02-20)
      Abstract. The effect of high altitude on reducing birth weight is markedly less in populations of high- (e.g., Andeans) relative to low-altitude origin (e.g., Europeans). Uterine artery (UA) blood flow is greater ...

    • Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry? 

      Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A.; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reprod Sci., 2010-09)
      Abstract. Objective: This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors contribute ...

    • Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude? 

      Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reproductive Sciences, 2011)
      Abstract. Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...

    • High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude 

      Browne, Vaughn A; Toledo-Jaldín, Lilian; Dávila, R Daniela; López, Luis P; Yamashiro, Henry; Cioffi-Ragan, Darleen; Julian, Colleen Glyde; Wilson, Megan J; Bigham, Abigail W; Shriver, Mark D; Honigman, Benjamín; Vargas, Enrique; Roach, Robert; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2011)
      The reduction in infant birth weight and increased frequency of preeclampsia (PE) in high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...

    • Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude 

      Bigham, Abigail W; Julian, Colleen Glyde; Wilson, Megan J; Vargas, Enrique; Browne, Vaughn A.; Shriver, Mark D; Moore, Lorna G (Physiol Genomics, 2014-07-14)
      Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...