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Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...
Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia
(PEDIATRIC RESEARCH, 2003-02-18)
Abstract.
Infant mortality and stillbirth rates in Bolivia are high and birth weights are low compared with other South American countries. Most Bolivians live at altitudes of 2500 m or higher. We sought to determine the ...
Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents
(Am J Physiol Regul Integr Comp Physiol, 2007)
Multigenerational (Andean) compared with shorter-term (European) high-altitude
residents exhibit less hypoxia-associated reductions in birth
weight. Because differences in arterial O2 content are not responsible,
we ...
Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity
(J Clin Endocrinol Metab, 2014-08)
Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the
result of reduced aromatase activity.
Objective: We asked whether the chronic hypoxia of residence at high altitude in the ...
A genomewide admixture mapping panel for hispanic/latino populations
(The American Journal of Human Genetics, 2007-06)
Admixture mapping (AM) is a promising method for the identification of genetic risk factors for complex traits and
diseases showing prevalence differences among populations. Efficient application of this method requires the ...
Does chronic mountain sickness (CMS) have perinatal origins?
(Respiratory Physiology & Neurobiology, 2007-06-29)
Abstract.
Chronic mountain sickness (CMS) occurs in 10% of male high-altitude residents. It is characterized by hypoventilation and hypoxemia but its underlying cause remains unknown. We hypothesized that CMS' origins ...
Evidence that parent-of-origin affects birth-weight reductions at high altitude
(American Journal of Human Biology, 2008-02-19)
Abstract.
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high-altitude populations are relatively protected from this birth-weight decline, ...
Consensus statement on chronic and subacute high altitude diseases
(High Altitude Medicine & Biology, 2005)
ABSTRACT.
This is an international consensus statement of an ad hoc committee formed by the In
ternational Society for Mountain Medicine (ISMM) at the VI World Congress on Mountain Med
icine and High Altitude Physiology ...
Increased incidence of preeclampsia lowers birth weight and increases intrauterine mortality at high altitude
(High Altitude Medicine & Biology, 2001)