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Apolipoprotein E/C1/C4/C2 gene cluster diversity in two native andean populations : Aymaras and Quechuas
(Annals of Human Genetics, 2012-07)
Summary.
The APOE/C1/C4/C2 gene cluster presents high relevance in lipid metabolism and, therefore, has important epidemiological implications. Here, we study for the first time the variation patterns of 25 polymorphisms ...
Increasing respiratory dead space improves sleep disordered breathing and hypoxemia in patients with chronic mountain sickness
(The FASEB Journal, 2011-04-25)
Sleep-disordered breathing and vascular function in patients with chronic mountain sickness and healthy high-altitude dwellers
(CHEST, 2016-11-05)
BACKGROUND: Chronic mountain sickness (CMS) is often associated with vascular
dysfunction, but the underlying mechanism is unknown. Sleep-disordered breathing (SDB)
frequently occurs at high altitude. At low altitude, ...
Reconstructing native American population history
(NATURE, 2012-08-16)
The peopling of the Americas has been the subject of extensive
genetic, archaeological and linguistic research; however, central
questions remain unresolved1–5. One contentious issue is whether
the settlement occurred ...
Exercise induces rapid interstitial lung water accumulation in patients with chronic mountain sickness
(CHEST, 2012-04-04)
Background: Chronic mountain sickness (CMS) is a major public health problem in mountainous
regions of the world. In its more advanced stages, exercise intolerance is often found, but the
underlying mechanism is not ...
Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness
(CHEST, 2010-02)
Background: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause ...
Exaggerated exercise-induced pulmonary hypertension causes lung water accumulation and right ventricular dysfunction in patients with chronic mountain sickness
(High Altitude Medicine & Biology, 2010-08-08)
Systemic vascular dysfunction in patients with chronic mountain sickness
(CHEST, 2012-01-01)
Background: Chronic mountain sickness (CMS) is a major public health problem characterized by
exaggerated hypoxemia and erythrocytosis. In more advanced stages, patients with CMS often
present with functional and structural ...
Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia
(Circulation, 2010-07-19)
Background—Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the ...
High altitude hypoxia and blood pressure dysregulation in adult chickens
(Journal of Developmental Origins of Health and Disease, 2013)
Although it is accepted that impaired placental perfusion in complicated pregnancy can slow fetal growth and programme an increased risk of cardiovascular dysfunction at adulthood, the relative contribution of reductions ...