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Increasing respiratory dead space improves sleep disordered breathing and hypoxemia in patients with chronic mountain sickness
(The FASEB Journal, 2011-04-25)
Autosomal and X chromosome alu insertions in Bolivian aymaras and quechuas : two languages and one genetic pool
(American Journal of Human Biology, 2010)
Abstract.
Thirty-two polymorphic Alu insertions (18 autosomal and 14 from the X chromosome) were studied in
192 individuals from two Amerindian populations of the Bolivian Altiplano (Aymara and Quechua speakers: the two ...
Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia
(Circulation, 2010-07-19)
Background—Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the ...
Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness
(CHEST, 2010-02)
Background: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause ...
mtDNA and y-chromosome diversity in aymaras and quechuas from Bolivia : different stories and special genetic traits of the andean altiplano populations
(American Journal of Physical Anthroplogy, 2011-04-05)
Abstract.
Two Bolivian samples belonging to the
two main Andean linguistic groups (Aymaras and Quechuas) were studied for mtDNA and Y-chromosome uniparental markers to evaluate sex-specific differences and
give new ...
Systemic vascular dysfunction in patients with chronic mountain sickness
(CHEST, 2012-01-01)
Background: Chronic mountain sickness (CMS) is a major public health problem characterized by
exaggerated hypoxemia and erythrocytosis. In more advanced stages, patients with CMS often
present with functional and structural ...
Reconstructing native American population history
(NATURE, 2012-08-16)
The peopling of the Americas has been the subject of extensive
genetic, archaeological and linguistic research; however, central
questions remain unresolved1–5. One contentious issue is whether
the settlement occurred ...
Exercise induces rapid interstitial lung water accumulation in patients with chronic mountain sickness
(CHEST, 2012-04-04)
Background: Chronic mountain sickness (CMS) is a major public health problem in mountainous
regions of the world. In its more advanced stages, exercise intolerance is often found, but the
underlying mechanism is not ...
Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia
(CHEST, 2013-02-01)
Background: Acute exposure to high altitude stimulates free radical formation in lowlanders, yet
whether this persists during chronic exposure in healthy, well-adapted and maladapted highlanders suffering from chronic ...
High altitude hypoxia and blood pressure dysregulation in adult chickens
(Journal of Developmental Origins of Health and Disease, 2013)
Although it is accepted that impaired placental perfusion in complicated pregnancy can slow fetal growth and programme an increased risk of cardiovascular dysfunction at adulthood, the relative contribution of reductions ...