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Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
The relationship between perinatl hypoxia and sleep-disordered breathing in preclinical chronic mountain sickness
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: Chronic intermittent hypoxia due to sleepdisordered breathing is implicated as a potential etiological
factor for chronic mountain sickness (CMS). Whether sleepdisordered breathing precedes or results from ...
Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
(Reprod Sci., 2010-09)
Abstract.
Objective: This prospective study was designed to determine whether variation in angiogenic
(placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1])
factors contribute ...
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
(Am J Physiol Regul Integr Comp Physiol, 2011)
The reduction in
infant birth weight and increased frequency of preeclampsia (PE) in
high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
(Reproductive Sciences, 2011)
Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...
Role of cytokines in altitude-associated preeclampsia
(Pregnancy Hypertens, 2012-01)
Abstract.
Background: Preeclampsia (PE) is more common at high than low altitude and contributes
to the altitude-related decline in birth weight. Since inflammatory markers are implicated
in PE, we asked if such markers ...