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Factores predominantes en la etiopatogenia de la enfermedad de Monge (EPA) en La Paz, Bolivia (3.600 - 4.000 m.)
(IFEA, 1993)
Resumen.
Se presenta una síntesis de los principales estudios de la función respiratoria en pacientes portadores de la “Enfermedad de Monge” o Eritrocitosis Patológica de Altura (EPA), entidad nosológica de carácter ...
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas
(PLOS Genetics, 2012-03-08)
Abstract.
Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors.
Complex historical factors have resulted in varying proportions of ancestral contributions ...
Maternal oxygen delivery is not related to altitude- and ancestry-associated differences in human fetal growth
(J Physiol, 2007-09-16)
Fetal growth is reduced at high altitude, but the decrease is less among long-resident populations.
We hypothesized that greater maternal uteroplacental O2 delivery would explain increased
fetal growth in Andean natives ...
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
The role of perinatal hypoxia in the development of preclinical CMS
(High Altitude Medicine & Biology, 2010-08-08)
Graduated effects of high-altitude hypoxia and highland ancestry on birth size
(Pediatric Research, 2013-10-02)
Background: We present a cohort of ca. 25,000 birth
records from Bolivia of men and women who are currently
adults. We used this cohort to test the hypothesis that high
altitude reduces birth weight and that highland ...
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
(The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
Oxidative stress has been implicated in the uteroplacental
ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high
(>2500 m) vs low altitude. Since Andeans ...
Uterine artery blood flow, fetal hypoxia and fetal growth
(Philosophycal Transactions B, 2015-03-13)
Evolutionary trade-offs required for bipedalism and brain expansion influence
the pregnancy rise in uterine artery (UtA) blood flow and, in turn, reproductive
success. We consider the importance of UtA blood flow by ...
The relationship between perinatl hypoxia and sleep-disordered breathing in preclinical chronic mountain sickness
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: Chronic intermittent hypoxia due to sleepdisordered breathing is implicated as a potential etiological
factor for chronic mountain sickness (CMS). Whether sleepdisordered breathing precedes or results from ...
Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitutde (2013 Grover Conference series)
(Pulm Circ, 2015-03)
Abstract.
Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident
groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness
(CMS). We hypothesized ...