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Inhibition of peroxisome proliferator gamma (PPARɣ) : a potential link between chronic maternal hypoxia and impaired fetal growth
(Journal of Women's Health, 2013)
Background and Objective: Chronic maternal hypoxia impairs
fetal growth and increases the incidence of intrauterine growth restriction (IUGR). To identify the mechanisms underlying these hypoxia-related effects, we evaluated ...
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas
(PLOS Genetics, 2012-03-08)
Abstract.
Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors.
Complex historical factors have resulted in varying proportions of ancestral contributions ...
Apolipoprotein E/C1/C4/C2 gene cluster diversity in two native andean populations : Aymaras and Quechuas
(Annals of Human Genetics, 2012-07)
Summary.
The APOE/C1/C4/C2 gene cluster presents high relevance in lipid metabolism and, therefore, has important epidemiological implications. Here, we study for the first time the variation patterns of 25 polymorphisms ...
Evidence for extraplacental sources of circulating angiogenic growth effectors in human pregnancy
(Placenta, 2013-08-24)
Abastract.
Pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are
associated with reduced blood flow, contributing to placental and fetal hypoxia. Placental hypoxia is
thought ...
The impact of altitude on the sleep of young elite soccer players (ISA3600)
(Br J Sports Med, 2013-01-28)
Abstract.
Background: Altitude training is used by elite athletes
to improve sports performance, but it may also disrupt
sleep. The aim of this study was to examine the effects
of 2 weeks at high altitude on the sleep ...
The sleep of elite athletes at sea level and high altitude : a comparison of sea-level natives and high-altitude natives (ISA3600)
(Br J Sports Med, 2013-09-03)
Abstract.
Background: Altitude exposure causes acute sleep
disruption in non-athletes, but little is known about its
effects in elite athletes. The aim of this study was to
examine the effects of altitude on two groups ...
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity
(J Clin Endocrinol Metab, 2014-08)
Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the
result of reduced aromatase activity.
Objective: We asked whether the chronic hypoxia of residence at high altitude in the ...
Genetic variations in the TP53 pathway in native americans strongly suggest adaptation to the high altitudes of the andes
(PLOS One, 2015-09-18)
Abstract.
The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and
LIF, rs929271) were studied in a total of ...