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Erythropoietin (EPO) in human milk : potential enteral factor in high altitude hypoxia
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: Erythropoietin (Epo) is a normal constituent of
human milk. At sea level, it was found that mean milk-borne
Epo concentrations are within the normal range for plasma
Epo concentrations and rise with ...
Divergent mitochondrial antioxidant activities and lung alveolar architecture in the lungs of rats and mice at high altitude
(Frontiers in Physiology, 2018)
Abstract.
Compared with mice, adult rats living at 3,600 m above sea level (SL—La Paz, Bolivia) have high hematocrit, signs of pulmonary hypertension, and low lung volume with reduced alveolar surface area. This phenotype ...
Programmation prénatale de l'acclimatation hématologique et respiratoire chez des rats de haute altitude
(Actas Club Recherché Clinique de Quebec, 2011)
Nous avons testé l’hypothèse selon laquelle l’hypoxie prénatale chez le rat aurait des
conséquences à long terme sur l’acclimatation physiologique à la haute altitude. Des rats
vivant en haute altitude (3600m, La Paz, ...
Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia : apnea of prematurity and sex dimorphism
(Experimental Neurology, 2019)
Abstract.
Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data ...
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
(J Appl Physiol., 2012)
Abstract.
We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA ...
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction
(Am J Physiol Heart Circ Physiol, 2015-04-27)
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and
attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ
Physiol 309: H565–H573, 2015. First published June 19, 2015;
doi:10.1152/a ...
Divergent physiological responses in laboratory rats and mice raised at high altitude
(The Journal of Experimental Biology, 2015-01-29)
Abstract.
Ecological studies show that mice can be found at high altitude (HA – up to 4000 m) while rats are absent at these altitudes, and there are
no data to explain this discrepancy. We used adult laboratory rats ...
Hematocrit and hemoglobin levels at adulthood are determined by neonatal hypoxic exposure in rats living at high altitude
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: In previous work performed at sea level we
reported that exposure to neonatal hypoxia impairs ventilatory and hematological responses to chronic hypoxia later in
life. These findings supported the hypothesis ...
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
(J Appl Physiol, 2012-03-13)
We tested the hypothesis that exposure of high-altitude (HA) rats to a period of
postnatal normoxia has long-term consequences on the ventilatory and
hematological acclimatization in adults. Male and female HA rats
(3,600 ...