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Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia
(Circulation, 2010-07-19)
Background—Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the ...
Hypoglycemia and the origin of hypoxia-induced reduction in human fetal growth
(PLOS One, 2010-01)
Abtract.
Background: The most well known reproductive consequence of residence at high altitude (HA .2700 m) is reduction in
fetal growth. Reduced fetoplacental oxygenation is an underlying cause of pregnancy pathologies, ...
The role of perinatal hypoxia in the development of preclinical CMS
(High Altitude Medicine & Biology, 2010-08-08)
Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth factors : the emperor's got no clothes?
(The Journal of Clinical Endocrinology & Metabolism, 2010)
ABSTRACT.
Context: Placental hypoxia alters production of angiogenic growth factors (AGFs), thought to be
causally involved in the development of the pregnancy-specific disease preeclampsia (PE).
Consistent with this, ...
Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness
(CHEST, 2010-02)
Background: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause ...
Cardiac and vascular disease prior to hatching in chick embryos incubated at high altitude
(Journal of Developmental Origins of Health and Disease, 2010)
Abstract.
The partial contributions of reductions in fetal nutrition and oxygenation to slow fetal growth and a developmental origin of cardiovascular disease remain unclear. By combining high altitude with the chick ...