Specific and sensitive immunological diagnosis of Chagas'disease by competitive antibody enzime immunoassay using a Trypanosoma cruzi-specific monoclonal antibody
Fecha
1986Autor
Lemesre, JL
Afchain, D
Orozco, O
Loyens, M
Brenière, FS
Desjeux, P
Carlier, Y
Martin, U
Nogueira-Queiroz, JA
Le Ray, D
Capron, A
Metadatos
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Ábstract.
Coexistence of Chagas' disease with leishmaniasis and T. rangeli infection in
endemic areas and cross-reactivity between corresponding etiological agents can confuse
the inmunodiagnosis of Chagas' disease. A discriminative serological test could therefore
represent a major advance in specifc immunodiagnosis. A competitive antibody enzyme
immunoassay against acomponent 5-enriched preparation, using a T. cruzi species-specific
monoclonal antibody has allowed development of a specific serodiagnosis of Chagas'
disease with high sensitivity (96.6% in undetermined and chronic phases of infection). This
test can differentiate Chagas' disease from other cross-reacting parasitic diseases in areas
where concomitant infections are unknown or suspected.