Effect of natural Naphtoquinones in BALB/C mice infected with Leishmania amazonensis and L. Venezuelensis
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Plumbagin (1), 3,3'-biplumbagin (2) and 8,8'-biplumbagin (3) are naphtoquinones isolated by activity-directed fractionation from a Bolivian plant, Pera benensis, employed in folk medicine as treatment of cutaneous Ieishmaniasis caused by Leishmania braziliensis. BALB/C mice were infected with Leishmania mexicana or Leishmania venezuelensis and treated 24h after the parasitic infection with plumbagin (5 or 2.5 mg kg-1 day-1), 3,3'- biplumbagin, 8,8'- biplumbagin (25 mg kg-1 day-1) or Glucantimer (200 mg kg-1 day-1). Lesion development was the criteria employed to evaluate the inhibitory effect ...