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Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
(Reprod Sci., 2010-09)
Abstract.
Objective: This prospective study was designed to determine whether variation in angiogenic
(placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1])
factors contribute ...
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
(The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
Oxidative stress has been implicated in the uteroplacental
ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high
(>2500 m) vs low altitude. Since Andeans ...
Andean and Tibetan patterns of adaptation to high altitude
(American Journal of Human Biology, 2013-01-24)
Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the
ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...