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Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth factors : the emperor's got no clothes?
(The Journal of Clinical Endocrinology & Metabolism, 2010)
ABSTRACT.
Context: Placental hypoxia alters production of angiogenic growth factors (AGFs), thought to be
causally involved in the development of the pregnancy-specific disease preeclampsia (PE).
Consistent with this, ...
Hypoglycemia and the origin of hypoxia-induced reduction in human fetal growth
(PLOS One, 2010-01)
Abtract.
Background: The most well known reproductive consequence of residence at high altitude (HA .2700 m) is reduction in
fetal growth. Reduced fetoplacental oxygenation is an underlying cause of pregnancy pathologies, ...
Evidence for extraplacental sources of circulating angiogenic growth effectors in human pregnancy
(Placenta, 2013-08-24)
Abastract.
Pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are
associated with reduced blood flow, contributing to placental and fetal hypoxia. Placental hypoxia is
thought ...
Maternal and fetoplacental hypoxia do not alter circulating angiogenec growth effectors during human pregnancy
(Biol Reprod., 2014-02-27)
Abstract.
One causal model of preeclampsia (PE) postulates that
placental hypoxia alters the production of angiogenic growth
effectors (AGEs), causing an imbalance leading to maternal
endothelial cell dysfunction. We ...