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Andean and Tibetan patterns of adaptation to high altitude
(American Journal of Human Biology, 2013-01-24)
Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the
ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
Uterine artery blood flow, fetal hypoxia and fetal growth
(Philosophycal Transactions B, 2015-03-13)
Evolutionary trade-offs required for bipedalism and brain expansion influence
the pregnancy rise in uterine artery (UtA) blood flow and, in turn, reproductive
success. We consider the importance of UtA blood flow by ...
Andean compared with european women are protected from altitude-associated intrauterine growth restriction (IUGR)
(s.n., 2003)
Abstract.
Babies born at high altitude to long-term high-altitude residents weigh more than those of recent migrants from low altitude. Objective: We asked whether a gradient exists such that persons of Andean ancestry ...
Human physiological adaptation to pregnancy : inter- and intrspecific perspectives
(American Journal of Human Biology, 2003)
Abstract.
Reproductive success requires successful maternal physiological adaptation to pregnancy. An interspecific perspective reveals that the human species has modified features of our haplorhine heritage affecting ...
Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitutde (2013 Grover Conference series)
(Pulm Circ, 2015-03)
Abstract.
Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident
groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness
(CMS). We hypothesized ...
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...
Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents
(Am J Physiol Regul Integr Comp Physiol, 2007)
Multigenerational (Andean) compared with shorter-term (European) high-altitude
residents exhibit less hypoxia-associated reductions in birth
weight. Because differences in arterial O2 content are not responsible,
we ...
Determinants of blood oxygenation during pregnancy in Andean and Europeas residents of high altitude
(Am J Physiol Regul Integr Comp Physiol, 2007-07-02)
High altitude decreases birth weight,
but this effect is diminished in long vs. short-resident, high-altitude
populations. We asked whether women from long vs. short-resident,
high-altitude populations had higher arterial ...