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Antileishmanial activity of a tetralone isolated from ampelocera edentula, a Bolivian plant used as a treatment for cutaneous Leishmaniasis
dc.contributor.author | Fournet, A | |
dc.contributor.author | Angelo Barrios, A | |
dc.contributor.author | Muñoz, V | |
dc.contributor.author | Hocquemiller, R | |
dc.contributor.author | Roblot, F | |
dc.contributor.author | Cavé, A | |
dc.date.accessioned | 2019-06-06T13:31:00Z | |
dc.date.available | 2019-06-06T13:31:00Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/21110 | |
dc.description.abstract | Abstract. The stem bark of Ampelocera edentula Kuhlm. (Ulmaceae) is used by the Chimanes Indians from Bolivia for the treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. A chloroform extract of the stem barks was found to be active against extracellular forms of Leishmania ssp. and Trypanosoma cruzi at 50 micrograms/ml. Bioassay-guided fractionation of this extract allowed us to isolate one active compound. Its structure was elucidated by spectral and chemical studies as 4-hydroxy-1-tetralone. BALB/c mice infected with L. amazonensis (PH8) or L. venezuelensis were treated one day after the parasitic infection with 4-hydroxy-1-tetralone (25 mg/kg/day) or with reference drug, Glucantime (56 mg Sbv/kg/day) for 14 days. Lesion development was the criteria used to evaluate the disease severity. 4-Hydroxy-1-tetralone was slightly less effective than the reference drug against L. amazonensis or L. venezuelensis. Single treatment near the site of infection, 14 days after infection with L. amazonensis, with 4-hydroxy-1-tetralone (50 mg/kg) was more effective than Glucantime (112 mg/kg). This study is, to our knowledge, the first to show the activity of a tetralone for the experimental treatment of New World cutaneous leishmaniasis. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | PLANTA MÉDICA | es_ES |
dc.subject | LEISHMANIASIS CUTÁNEA | es_ES |
dc.subject | LEISHMANIA SSP | es_ES |
dc.subject | TRYPANOSOMA CRUZI | es_ES |
dc.subject | ACTIVIDAD LEISHMANICIDA | es_ES |
dc.subject | ACTIVIDAD TRIPANOCIDA | es_ES |
dc.title | Antileishmanial activity of a tetralone isolated from ampelocera edentula, a Bolivian plant used as a treatment for cutaneous Leishmaniasis | es_ES |
dc.type | Article | es_ES |