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The activity of 2-substituted quinoline alkaloids in BALB/c mice infected with Leishmanis donovani
dc.contributor.author | Fournet, A | |
dc.contributor.author | Gantier, JC | |
dc.contributor.author | Gautheret, A | |
dc.contributor.author | Leysalles, L | |
dc.contributor.author | Munos, MH | |
dc.contributor.author | Mayrargue, J | |
dc.contributor.author | Moskowitz, H | |
dc.contributor.author | Cavé, A | |
dc.contributor.author | Hocquemiller, R | |
dc.date.accessioned | 2019-06-05T18:22:03Z | |
dc.date.available | 2019-06-05T18:22:03Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/21087 | |
dc.description.abstract | Abstract. Potent antileishmanial activity has recently been described in vivo when certain 2-substituted quinoline alkaloids are administered to mice with cutaneous leishmaniasis. We now report the ahtileishmanial activity of four 2-substituted quinoline alkaloids, namely chimanine D or 2-(1',2'-trans-epoxypropyl) quinoline (I). 2-n- propylquinoline (II), 2-styrylquinoline (III) and 2-(2'-hydroxypropyl) quinoline (IV), for experimental treatment of visceral leishmaniasis in infected BALB/c mice. Subcutaneous treatment with chimanine D for 10 days at 0-54 mmol/kg per day resulted in 86.6% parasite suppression in the liver. Oral administration of 0-54 mmol/kg of 2-n-propylquinoline once daily for 5 or 10 days to L. donovani-nfected mice suppressed parasite burdens in liver by 87.8 and 99.9%. respectively. Cutaneous administration of meglumine antimonate for 10 days resulted in 97.4% parasite suppression in the liver. This study is, to our knowledge, the first to demonstrate the activity of 2-substituted quinoline alkaloids in experimental treatment of visceral leishmaniasis. Further biological and chemical studies of these products might yet prove helpful for the development of new antileishmanial drugs. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Journal of Antimicrobial Chemotherapy | es_ES |
dc.subject | LEISHMANIASIS | es_ES |
dc.subject | LEISHMANIA DONOVANI | es_ES |
dc.subject | RATONES INFECTADOS | es_ES |
dc.title | The activity of 2-substituted quinoline alkaloids in BALB/c mice infected with Leishmanis donovani | es_ES |
dc.type | Article | es_ES |