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Effect of some bisbenzylisoquinoline alkaloids on American Leishmania sp. in BALB/c mice
dc.contributor.author | Fournet, Alain | |
dc.contributor.author | Angelo Barrios, Alcira | |
dc.contributor.author | Muñoz, Victoria | |
dc.contributor.author | Hocquemiller, Reynald | |
dc.contributor.author | Cavé, André | |
dc.date.accessioned | 2019-05-28T18:36:56Z | |
dc.date.available | 2019-05-28T18:36:56Z | |
dc.date.issued | 1993 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/20743 | |
dc.description.abstract | Abstract. Four bisbenzylisoquinoline alkaloids, antioquine, berbamine, gyrocarpine and isotetrandrine were tested in BALB/c mice infected with Leishmania amazonensis (IFLA/BR/67/PH8 or MHOM/GF/84/CAY-H-142) or L. venezuelensis (VE/74/PM-H3). The treatments were initiated 1 day after the parasitic infection, with alkaloid at 100 mg/kg/day for 14 days and the reference compound, meglumine antimonate (GlucantimeR) at 200 mg/kg/day. Antioquine, berbamine and gyrocarpine were less potent than Glucantime against L. amazonensis (PH8). Only isotetrandrine exhibited activity approximately equal to or greater than Glucantime in BALB/c mice infected with L. amazonensis (PH8 or H-142) and showed significant activity against L. venezuelensis. Experiments with a single local treatment on the footpad, 2 weeks after parasitic infection with L. amazonensis (PH8), showed that isotetrandrine at 200 mg/kg was less active than Glucantime at 400 mg/kg. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | PHYTOTHERAPY RESEARCH | es_ES |
dc.subject | BERBAMINA | es_ES |
dc.subject | ISOTETRANDRINA | es_ES |
dc.subject | BALB/c | es_ES |
dc.subject | LEISHMANIA AMAZONENSIS | es_ES |
dc.subject | LEISHMANIA VENEZUELENSIS | es_ES |
dc.title | Effect of some bisbenzylisoquinoline alkaloids on American Leishmania sp. in BALB/c mice | es_ES |
dc.type | Article | es_ES |