Plasma antioxidant capacity in highland subjects exposed at 5200 meters of altitude
Fecha
2014-06-30Autor
Negrón Arroyo, Claudia C
Peredo Núñez de Arco, Rossana K
Fernández Pinto, J. Víctor
Fuentes Zenteno, Catalina S
Bravo, José A
Alvarado, Juan Antonio
Soria, Rudy
Peñarrieta, J. Mauricio
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Abstract.
Human exposure to high altitude conditions (reduced barometric pressure) leads to the formation of free radicals,
which could be a major cause of altitude sickness. In the present study the total antioxidant capacity (TAC) was
measured by two methods, FRAP (ferric reducing antioxidant power) and ABTS (2,2 '-azino-bis-3-6-sulfonic acid
ethylbenzotiazolin acid) in the blood plasma samples of 15 non-smoking Bolivians (10 men and 5 women), who were
exposed to large changes in altitude from 3,600 to 5,200 meters. The average antioxidant activity for ABTS at 3600 m
was 560 µmol Trolox Equivalent./l of plasma and for FRAP 569 µmol Trolox Equivalent./l of plasma.. .After exposure
to 5200 m, the ABTS and FRAP showed an increment in average of 602 µmol Trolox Equivalent./l of plasma and 642
µmol Trolox Equivalent./l of plasma. Both methods showed a high linear correlation for all samples. After exposure of
subjects to extreme altitude, the results showed a significant increase in the level of antioxidants in blood plasma
samples especially for the FRAP method.