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Perinatal origins of chronic mountain sickness : the role of perinatal hypoxia in the development of CMS
(Meeting VII Congress World Medicine and Physiology High Altitude, 2011)
The role of perinatal hypoxia in the development of preclinical CMS
(High Altitude Medicine & Biology, 2010-08-08)
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
(Am J Physiol Regul Integr Comp Physiol, 2011)
The reduction in
infant birth weight and increased frequency of preeclampsia (PE) in
high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
(American Journal of Human Biology, 2011-04-27)
Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important
determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ...
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
(Reproductive Sciences, 2011)
Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
(The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
Oxidative stress has been implicated in the uteroplacental
ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high
(>2500 m) vs low altitude. Since Andeans ...
Role of cytokines in altitude-associated preeclampsia
(Pregnancy Hypertens, 2012-01)
Abstract.
Background: Preeclampsia (PE) is more common at high than low altitude and contributes
to the altitude-related decline in birth weight. Since inflammatory markers are implicated
in PE, we asked if such markers ...
Andean and Tibetan patterns of adaptation to high altitude
(American Journal of Human Biology, 2013-01-24)
Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the
ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
Maternal and fetoplacental hypoxia do not alter circulating angiogenec growth effectors during human pregnancy
(Biol Reprod., 2014-02-27)
Abstract.
One causal model of preeclampsia (PE) postulates that
placental hypoxia alters the production of angiogenic growth
effectors (AGEs), causing an imbalance leading to maternal
endothelial cell dysfunction. We ...
Uterine artery blood flow, fetal hypoxia and fetal growth
(Philosophycal Transactions B, 2015-03-13)
Evolutionary trade-offs required for bipedalism and brain expansion influence
the pregnancy rise in uterine artery (UtA) blood flow and, in turn, reproductive
success. We consider the importance of UtA blood flow by ...