Role of cytokines in altitude-associated preeclampsia
Fecha
2012-01Autor
Dávila, R Daniela
Julian, Colleen Glyde
Browne, Vaughn A.
Toledo-Jaldín, Lillian
Wilson, Megan J
Rodríguez, Armando
Vargas, Enrique
Moore, Lorna G
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Abstract.
Background: Preeclampsia (PE) is more common at high than low altitude and contributes
to the altitude-related decline in birth weight. Since inflammatory markers are implicated
in PE, we asked if such markers differed in PE vs. normotensive pregnant (NORM) women
residing at high altitudes (3600–4100 m), and were related to uterine artery blood flow (UA
BF) or fetal growth.
Methods: Subjects were 33 Andean pregnant residents of Bolivia, comprising six with earlyonset PE (634 wks), 12 with late-onset PE (>34 wks), and 15 gestational-age-matched NORM.
Maternal pro- and anti-inflammatory cytokines were measured using a multiplex beadbased assay and UA BF by Doppler ultrasound.
Results: PE compared to NORM women had higher levels of the pro-inflammatory cytokines
IL-6 and IL-8 as well as higher levels of the anti-inflammatory cytokine IL-1ra, but only IL-6
levels were higher when gestational age was controlled. Women with early- vs. late-onset PE
had higher TNFa levels, and higher IL-6 was negatively correlated with birth weight in all
women at 634 wks. We suggest that pro-inflammatory factors influence both the timing
and severity of PE at high altitude.