Listar Producción científica por autor "Gonzales, Marcelino"
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Comparative responses of arterial oxygen saturation and heart rate durign postnatal development in rats living at high and low altitude
Lemoine, Alejandra Jochmans; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)We used pulse oximetry to measure arterial oxygen saturation (SpO2) and heart rate (HR) in 4 and 14 day-old rats raised at HA (La Paz, Bolivia, 3,600 m / 12,000ft) or at sea level (SL, Québec, Canada). SpO2 and HR were ... -
Divergent mitochondrial antioxidant activities and lung alveolar architecture in the lungs of rats and mice at high altitude
Jochmans-Lemoine, Alexandra; Revollo, Susana; Villalpando, Gabriela; Valverde, Ibana; Gonzales, Marcelino; Laouafa, Sofien; Soliz, Jorge; Joseph, Vincent (Frontiers in Physiology, 2018)Abstract. Compared with mice, adult rats living at 3,600 m above sea level (SL—La Paz, Bolivia) have high hematocrit, signs of pulmonary hypertension, and low lung volume with reduced alveolar surface area. This phenotype ... -
Divergent physiological responses in laboratory rats and mice raised at high altitude
Jochmans-Lemoine, Alejandra; Villalpando, Gabriela; Gonzales, Marcelino; Valverde, Ibana; Soria, Rudy; Joseph, Vincent (The Journal of Experimental Biology, 2015-01-29)Abstract. Ecological studies show that mice can be found at high altitude (HA – up to 4000 m) while rats are absent at these altitudes, and there are no data to explain this discrepancy. We used adult laboratory rats ... -
Effects of prenatal hypoxia on hematological and respiratory acclimatization to high altitude in rats
Lemoine, Alejandra Jochmans; Lumbroso, Delphine; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)We tested the hypothesis that prenatal hypoxia have long-term consequences on physiological acclimatization to high altitude in rats. Male and female high-altitude rats (3600m, La Paz, Bolivia) were exposed to normal ... -
Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude
Seaborn, Tommy; Gonzales, Marcelino; Villalpando, Gabriela; Grenacher, Beat; Soria, Rudy; Soliz, Jorge (Neuroscience Letters, 2011)Abstract. In addition to its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions against acute and delayed degenerative diseases of the brain. Moreover, we have recently demonstrated that ... -
Erythropoietin (EPO) in human milk : potential enteral factor in high altitude hypoxia
Gonzales, Marcelino; Bellido, Diva; Soliz, Jorge (High Altitude Medicine & Biology, 2010-08-08)Introduction: Erythropoietin (Epo) is a normal constituent of human milk. At sea level, it was found that mean milk-borne Epo concentrations are within the normal range for plasma Epo concentrations and rise with ... -
Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia : apnea of prematurity and sex dimorphism
Laouafa, Sofien; Iturri, Pablo; Arias-Reyes, Christian; Marcouiller, François; Gonzales, Marcelino; Joseph, Vincent; Bairam, Aida; Soliz, Jorge (Experimental Neurology, 2019)Abstract. Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data ... -
Hematocrit and hemoglobin levels at adulthood are determined by neonatal hypoxic exposure in rats living at high altitude
Lumbroso, Delphine; Villalpando, Gabriela; Gonzales, Marcelino; Soria Sánchez, Rudy; Joseph, Vincent (High Altitude Medicine & Biology, 2010-08-08)Introduction: In previous work performed at sea level we reported that exposure to neonatal hypoxia impairs ventilatory and hematological responses to chronic hypoxia later in life. These findings supported the hypothesis ... -
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
Lumbroso, Delphine; Lemoine, Alexandra; Gonzales, Marcelino; Villalpando, Gabriela; Seaborn, Tommy; Joseph, Vincent (J Appl Physiol., 2012)Abstract. We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA ... -
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
Lumbroso, Delphine; Lemoine, Alejandra Jochmans; Gonzales, Marcelino; Villalpando, Gabriela; Seaborn, Tommy; Joseph, Vincent (J Appl Physiol, 2012-03-13)We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA rats (3,600 ... -
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction
Julian, Colleen Glyde; Gonzales, Marcelino; Rodríguez, Armando; Bellido, Diva; Salinas Salmón, Carlos; Ladenburger, Anne; Reardon, Lindsay; Vargas, Enrique; Moore, Lorna G (Am J Physiol Heart Circ Physiol, 2015-04-27)Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol 309: H565–H573, 2015. First published June 19, 2015; doi:10.1152/a ... -
Perinatal origins of chronic mountain sickness : the role of perinatal hypoxia in the development of CMS
Vargas, Enrique; Julian, Colleen Glyde; Salinas Salmón, Carlos E; Dávila, Daniela; Rodríguez, Armando; Gonzales, Marcelino; Moore, Lorna G (Meeting VII Congress World Medicine and Physiology High Altitude, 2011) -
Programmation prénatale de l'acclimatation hématologique et respiratoire chez des rats de haute altitude
Lemoine, Alejandra Jochmans; Lumbroso, Delphine; Villalpando, Gabriela; Gonzales, Marcelino; Soria, Rudy; Joseph, Vincent (Actas Club Recherché Clinique de Quebec, 2011)Nous avons testé l’hypothèse selon laquelle l’hypoxie prénatale chez le rat aurait des conséquences à long terme sur l’acclimatation physiologique à la haute altitude. Des rats vivant en haute altitude (3600m, La Paz, ... -
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
Julian, Colleen Glyde; Vargas, Enrique; Gonzales, Marcelino; Dávila, R Daniela; Ladenburger, Anne; Reardon, Lindsay; Schoo, Caroline; Powers, Robert W; Lee-Chiong, Teofilo; Moore, Lorna G (Respiratory Physiology & Neurobiology, 2013-01-22)Abstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores ... -
The relationship between perinatl hypoxia and sleep-disordered breathing in preclinical chronic mountain sickness
Julian, Colleen Glyde; Vargas, Enrique; Dávila, R Daniela; Salinas Salmón, Carlos E; Rodríguez, A; Gonzales, Marcelino; Moore, Lorna G (High Altitude Medicine & Biology, 2010-08-08)Introduction: Chronic intermittent hypoxia due to sleepdisordered breathing is implicated as a potential etiological factor for chronic mountain sickness (CMS). Whether sleepdisordered breathing precedes or results from ... -
Unique DNA methylation patterns in offspring of hypertensive pregnancy
Julian, Colleen Glyde; Pedersen, Brent S; Salinas Salmón, Carlos; Yang, Ivana V; Gonzales, Marcelino; Vargas, Enrique; Moore, Lorna G; Schwartz, David A (Clin Transl Sci., 2015)Abstract. Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...