Listar Producción científica por autor "Villena, Mercedes"

Mostrando ítems 21-40 de 64

    • Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness 

      Stuber, Thomas; Sartori, Claudio; Schwab, Marcos; Jayet, Pierre-Yves; Rimoldi, Stefano F; Garcin, Sophie; Thalmann, Sébastien; Spielvogel, Hilde; Salinas Salmón, Carlos E; Villena, Mercedes; Scherrer, Urs; Allemann, Yves (CHEST, 2010-02)
      Background: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause ...

    • Exaggerated systemic oxidative-inflammatory-nitrosative stress in chronic mountain sIckness is associated with cognitive decline and depression 

      Bailey, Damian M; Brugniaux, Julien V; Filipponi, Teresa; Marley, Christopher J; Stacey, Benjamin; Soria, Rodrigo; Rimoldi, Stefano F; Cerny, David; Rexhaj, Emrush; Pratali, Lorenza; Salinas Salmón, Carlos; Murillo Jáuregui, Carla; Villena, Mercedes; Smirl, Jonathan D; Ogoh, Shigehiko; Pietri, Sylvia; Scherrer, Urs; Sartori, Claudio (J Physiol, 2019)
      Abstract. Chronic mountain sickness (CMS) is a maladaptation syndrome encountered at high altitude (HA) characterised by severe hypoxaemia that carries a higher risk of stroke and migraine and is associated with increased ...

    • Excessive polycythemia occurs in young high-altitude (3600 m) residents in the absence o lung disease 

      Vargas, Enrique; Villena, Mercedes; Salinas, Carlos; Rodríguez, Armando; Téllez, Wilma; Spielvogel, Hilde; Bellido, Diva (Health & height proceeding, 2002)
      Summary. Chronic mountain sickness is present in about 8% of the male population of La Paz. Our question was whether its principal diagnostic sign, excessive polycythemia (EP) without lung disease could be found already ...

    • Excessive polycythemia occurs in young high-altitude (3600 M) residents in the absence of lung disease 

      Vargas, Enrique; Villena, Mercedes; Salinas Salmón, Carlos E; Rodríguez, Armando; Spielvogel, Hilde; Téllez, Wilma; Bellido, Diva (High Altitude Medicine & Biology, 2002-04-18)
      Objective: Chronic Mountain Sickness occurs in , 8% of the La Paz population. We asked whether its primary diagnostic sign, excessive polycythemia (EP), occurred in youngeraged persons without lung disease. Methods: ...

    • Exercise induces rapid interstitial lung water accumulation in patients with chronic mountain sickness 

      Pratali, Lorenza; Rimoldi, Stefano F; Rexhaj, Emrush; Hutter, Damian; Faita, Francesco; Salinas Salmón, Carlos E; Villena, Mercedes; Sicari, Rosa; Picano, Eugenio; Allemann, Yves; Scherrer, Urs; Sartori, Claudio (CHEST, 2012-04-04)
      Background: Chronic mountain sickness (CMS) is a major public health problem in mountainous regions of the world. In its more advanced stages, exercise intolerance is often found, but the underlying mechanism is not ...

    • Fútbol en la altura en Bolivia 

      Spielvogel, Hilde; Vargas, Enrique; Soria Sánchez, Rudy; Salinas Salmón, Carlos E; Villena, Mercedes (Cuadernos del Hospital de Clínicas, 2009)
      RESUMEN. El presente trabajo se realizó en razón del tercer veto emitido por la FIFA, de jugar partidos eliminatorios para Copas Mundiales de Fútbol en alturas por encima de los 2500 m. Los objetivos del estudio se basaron ...

    • Genetic variations in the TP53 pathway in native americans strongly suggest adaptation to the high altitudes of the andes 

      Jacovas, Vanessa Cristina; Rovaris, Diego Luiz; Pérez, Orlando; Azevedo, Soledad de; Macedo, Gabriel Souza; Sandoval, José Raul; Salazar-Granara, Alberto; Villena, Mercedes; Dugoujon, Jean-Michel; Bisso-Machado, Rafael; Petzi-Erler, María Luiza; Salzano, Francisco Mauro; Ashton-Prolla, Patricia; Ramallo, Virginia; Bortolini, María Cátira (PLOS One, 2015-09-18)
      Abstract. The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of ...

    • Hallazgos de función pulmonar en pacientes con EPOC a 3.600 m.s.n.m. en el Instituto Boliviano de Biología de Altura 

      Murillo Jauregui, Carla; Romero, Catherine; Gonzales, Cristina; Alarcón, Ana María; Aguilar, Martha; Villena, Mercedes (COLEGIO MEDICO DE BOLIVIA, 2016-02)
      RESUMEN. El instituto Boliviano de Biología de Altura (IBBA) a parte de la investigación realiza venta de servicios de pruebas de Función Pulmonar a diferentes centros de salud, considerado centro de referencia a nivel ...

    • Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara 

      Beall, Cynthia M; Brittenham, Gary M; Strohl, Kingman P; Blangero, John; Williams-Blanguero, Sarah; Goldstein, Melvyn C; Decker, Michael J; Vargas, Enrique; Villena, Mercedes; Soria, Rudy; Alarcón, Ana María; Gonzales, Cristina (American Journal of Physical Anthropology, 1998)
      Abstract. Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing ...

    • La hemoglobina como factor de incremento en la difusión alvéolo-capilar en habitantes de altura 

      Vargas, Enrique; Villena, Mercedes; Videa, Ricardo; Nallar, Nancy de; Rodríguez, Nancy V. de; Pasquis, Pierre (Instituto Boliviano de Biología de Altura, 1983)
      RESUMEN. La capacidad de difusión alvéolo-capilar (DLCO) fue determinada usando el método en estado de equilibrio (Steady State) en nativos de altura (3.600 m). Se realizó un estudio estadístico mediante coeficientes de ...

    • Hemoglobinas en eritrocitósicos que habitan en altura 

      Galarza Guzmán, Mario; Vargas, Enrique; Villena, Mercedes (Instituto Boliviano de Biología de Altura, 1987)
      Resumen. Con el fin de establecer las alteraciones cuali-cuantitativas de las hemoglobinas en la eritrocitosis, se estudiaron las hemoglobinas de 68 pacientes, correspondiendo 54 casos a eritrocitosis secundaria y 14 a ...

    • High altitude hypoxia and blood pressure dysregulation in adult chickens 

      Herrera, EA; Salinas Salmón, Carlos E; Blanco, CE; Villena, Mercedes; Giussani, David A (Journal of Developmental Origins of Health and Disease, 2013)
      Although it is accepted that impaired placental perfusion in complicated pregnancy can slow fetal growth and programme an increased risk of cardiovascular dysfunction at adulthood, the relative contribution of reductions ...

    • High-altitude hypoxia and echocardiographic indices of pulmonary hypertension in male and female chickens at adulthood 

      Salinas Salmón, Carlos E; Blanco, Carlos E; Villena, Mercedes; Giussani, Dino A (Circulation Journal, 2014-06)
      Background: By combining the chick embryo model with incubation at high altitude (HA), the effects of chronic hypoxia on fetal growth, fetal cardiac and aortic wall remodeling and systemic arterial blood pressure at adulthood ...

    • Increasing respiratory dead space improves sleep disordered breathing and hypoxemia in patients with chronic mountain sickness 

      Rexhaj, Emrush; Rimoldi, Stefano F; Jayet, Pierre-Yves; Lovis, Alban; Andries, Daniela; Salinas Salmón, Carlos E; Villena, Mercedes; Allemann, Yves; Heinzer, Raphaël; Scherrer, Urs; Sartori, Claudio (The FASEB Journal, 2011-04-25)

    • Latin Americans show wide-spread converso ancestry and imprint of local native ancestry on physical appearance 

      Chacón-Duque, Juan-Camilo; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Mendoza-Revilla, Javier; Acuña-Alonzo, Víctor; Barquera, Rodrigo; Quinto-Sánchez, Mirsha; Gómez-Valdés, Jorge; Everardo Martínez, Paola; Villamil-Ramírez, Hugo; Hünemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Villena, Mercedes; Vásquez, René; Llop, Elena; Sandoval, José R; Salazar-Granara, Alberto; Parolin, María-Laura; Sandoval, Karla; Peñaloza-Espinoza, Rosenda I; Rangel-Villalobos, Héctor; Winkler, Cheryl A; Klitz, William; Bravi, Claudio; Molina, Julio; Corach, Daniel; Barrantes, Ramiro; Gomes, Verónica; Resende, Carlos; Gusmäo, Leonor; Amorin, Antonio; Xue, Yali; Dugoujon, Jean-Michel; Moral, Pedro; González-José, Rolando; Schuler-Faccini, Lavinia; Salzano, Francisco M; Bortolini, María-Cátira; Canizales-Quinteros, Samuel; Poletti, Giovanni; Gallo, Carla; Bedoya, Gabriel; Rothhammer, Francisco; Balding, David; Hellenthal, Garrett; Ruiz-Linares, Andrés (Nature communications, 2018)
      Abstract. Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based ...

    • Mecánica ventilatoria en pacientes con eritrocitosis de altura 

      Villena, Mercedes; Vargas, Enrique; Villena de Rodriguez, Nancy; Beaulieu, Pierre (Instituto Boliviano de Biología de Altura, 1979)
      Se trata de un análisis de los aspectos generales que intervienen en la mecánica ventilatoria así como los factores que determinan sus variaciones patológicas. Fueron estudiados 138 pacientes poliglobúlicos de los cuales ...

    • Mitochondrial DNA haplogroup B predominance in the aymara population living in the Andes 

      Ruiz, Emma; Villena, Mercedes; Rochet, Dominique; Godinot, Catherine ([s.n.], 2002)

    • mtDNA and y-chromosome diversity in aymaras and quechuas from Bolivia : different stories and special genetic traits of the andean altiplano populations 

      Gayà-Vidal, Magdalena; Moral, Pedro; Saenz-Ruales, Nancy; Gerbault, Pascale; Tonasso, Laure; Villena, Mercedes; Vasquez, René; Bravi, Claudio M; Dugoujon, Jean-Michel (American Journal of Physical Anthroplogy, 2011-04-05)
      Abstract. Two Bolivian samples belonging to the two main Andean linguistic groups (Aymaras and Quechuas) were studied for mtDNA and Y-chromosome uniparental markers to evaluate sex-specific differences and give new ...

    • Normal hematological values for healthy persons living at 4000 meters in Bolivia 

      Vásquez, René; Villena, Mercedes (High Altitude Medicine & Biology, 2001)
      Abstract. Vásquez, René, and Villena, Mercedes. Normal hematological values for healthy persons living at 4000 m in Bolivia. High AU Med BioI 2:361-367, 2001.-Defining the range of normal hematocrit and ...

    • Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension 

      Sartori, Claudio; Jayet, Pierre-Yves; Thalmann, Sebastien; Stuber, Thomas; Hutter, Damian; Salinas Salmón, Carlos E; Cucchia, Celine; Rodriguez, Armando; Riveros, Loyola; Spielvogel, Hilde; Allemann, Yves; Villena, Mercedes; Scherrer, Urs (High Altitude Medicine & Biology, 2005-02-22)
      Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors ...