Listar IBBA - Instituto Boliviano de Biología de la Altura por autor "Wilson, Megan J"
Mostrando ítems 1-11 de 11
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Andean and Tibetan patterns of adaptation to high altitude
Bigham, Abigail W; Wilson, Megan J; Julian, Colleen Glyde; Kiyamu, Melisa; Vargas, Enrique; León-Velarde, Fabiola; Rivera-Chira, María; Rodríguez, Carmelo; Browne, Vaughn A.; Parra, Esteban; Brutsaert, Tom D; Moore, Lorna G; Shriver, Mark D (American Journal of Human Biology, 2013-01-24)Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ... -
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
Julian, Colleen Glyde; Wilson, Megan J; López, Miriam; Yamashiro, Henry; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail W; Shriver, Mark D; Rodríguez, Carmelo; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2009-02-20)Abstract. The effect of high altitude on reducing birth weight is markedly less in populations of high- (e.g., Andeans) relative to low-altitude origin (e.g., Europeans). Uterine artery (UA) blood flow is greater ... -
Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A.; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reprod Sci., 2010-09)Abstract. Objective: This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors contribute ... -
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reproductive Sciences, 2011)Abstract. Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ... -
Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents
Wilson, Megan J; López, Miriam; Vargas, Marco; Julian, Colleen Glyde; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail; Armaza, J Fernando; Niermeyer, Susan; Shriver, Mark; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2007)Multigenerational (Andean) compared with shorter-term (European) high-altitude residents exhibit less hypoxia-associated reductions in birth weight. Because differences in arterial O2 content are not responsible, we ... -
High-altitude ancestry protects against hypoxia-associated reductions in fetal growth
Julian, Colleen Glyde; Vargas, Enrique; Armaza, J Fernando; Wilson, Megan J; Niermeyer, Susan; Moore, Lorna G (Archives of Disease in Childhood-Fetal and Neonatal, 2007-02-28)Objective: The chronic hypoxia of high-altitude (>2500 m) residence has been shown to decrease birth weight in all populations studied to date. However, multigenerational high-altitude populations appear protected relative ... -
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
Browne, Vaughn A; Toledo-Jaldín, Lilian; Dávila, R Daniela; López, Luis P; Yamashiro, Henry; Cioffi-Ragan, Darleen; Julian, Colleen Glyde; Wilson, Megan J; Bigham, Abigail W; Shriver, Mark D; Honigman, Benjamín; Vargas, Enrique; Roach, Robert; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2011)The reduction in infant birth weight and increased frequency of preeclampsia (PE) in high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ... -
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
Julian, Colleen Glyde; Hageman, Jennifer L; Wilson, Megan J; Vargas, Enrique; Moore, Lorna G (American Journal of Human Biology, 2011-04-27)Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ... -
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
Bigham, Abigail W; Julian, Colleen Glyde; Wilson, Megan J; Vargas, Enrique; Browne, Vaughn A.; Shriver, Mark D; Moore, Lorna G (Physiol Genomics, 2014-07-14)Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ... -
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
Julian, Colleen Glyde; Vargas, Enrique; Browne, Vaughn A.; Wilson, Megan J; Bigham, Abigail W; Rodríguez, Carmelo; McCord, Joe M; Moore, Lorna G (The Journal of Maternal-Fetal and Neonatal Medicine, 2012)Oxidative stress has been implicated in the uteroplacental ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high (>2500 m) vs low altitude. Since Andeans ... -
Role of cytokines in altitude-associated preeclampsia
Dávila, R Daniela; Julian, Colleen Glyde; Browne, Vaughn A.; Toledo-Jaldín, Lillian; Wilson, Megan J; Rodríguez, Armando; Vargas, Enrique; Moore, Lorna G (Pregnancy Hypertens, 2012-01)Abstract. Background: Preeclampsia (PE) is more common at high than low altitude and contributes to the altitude-related decline in birth weight. Since inflammatory markers are implicated in PE, we asked if such markers ...