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dc.contributor.authorMoretti, C
dc.contributor.authorDeharo, E
dc.contributor.authorSauvain, M
dc.contributor.authorJardel, C
dc.contributor.authorTimon David, P
dc.contributor.authorGasquet, M
dc.date.accessioned2019-06-14T13:32:36Z
dc.date.available2019-06-14T13:32:36Z
dc.date.issued1994
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/21372
dc.description.abstractAbstract. Cedronin was isolated from Simaba cedron Planchon (Simaroubaceae), a species popularly believed in South America to have antimalarial properties. It was examined for in vitro and in vivo antimalarial activities and for cytotoxicity against KB cells. Experimental results showed that cedronin was active against chloroquine-sensitive and resistant strain, with an IC₅₀ of 0.25 µg/ml (0.65 µmol/ml). It was also found to be active in vivo against Plasmodium vinkei with an IC₅₀ of 1.8 mg/kg (4.7 nM/kg) in the classic 4-day test. Cedronin belongs to the small group of quassinoids with a C₁₉ basic skeleton and shows a rather low cytotoxicity against KB cells (IC₅₀ = 4 µg/ml, 10.4 µM) as compared with C₂₀ biologically active quassinoids; however its toxic/therapeutic ratio (10/1.8) remains lower than chloroquine (10/0.5).es_ES
dc.language.isoenes_ES
dc.publisherJournal of Ethnopharmacologyes_ES
dc.subjectACTIVIDAD ANTIMALARIALes_ES
dc.subjectCEDRONINes_ES
dc.subjectSIMBA CEDRONes_ES
dc.titleAntimalarial activity of cedronines_ES
dc.typeArticlees_ES


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