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Étude en double insu de l'effect de l'almitrine sur les malades porteurs de polyglobulie pathologique d'altitude
dc.contributor.author | Villena, M | |
dc.contributor.author | Vargas, E | |
dc.contributor.author | Guénard, H | |
dc.contributor.author | Nallar, N | |
dc.contributor.author | Tellez, W | |
dc.contributor.author | Spielvogel, H | |
dc.date.accessioned | 2019-05-22T15:47:20Z | |
dc.date.available | 2019-05-22T15:47:20Z | |
dc.date.issued | 1985 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/20555 | |
dc.description.abstract | ABSTRACT. Chronic polycythaemia in people living at high altitude is associated with hypoxaemia due to a marked reduction in hypoxic and hypercapnie drives. The effect of almitrine, a chemoreceptor stimulant, was evaluated in 40 patients, with haematocrit values over 57 %, living in La Paz (3,600-4,000 m). Two studies were carried out. The aim of the first was to assess the ventilatory response, and the increase in Pao₂, due to almitrine in a double blind, placebo controlled protocol including 40 patients (mean haematocrit 66.8%). Almitrine was given orally at a dose of 3 mg. kg-1. Variance analysis showed that three hours later there was a significant increase in Pao₂, (+ 0.46 kPa), pH and respiratory frequency, with a significant reduction in Paco₂, (-- 0.4 kPa). The increase in ventilation (+ 17 %) was not significant. The aim of the second study was to assess the effect of almitrine on the polycythaemia. It was given orally at a dose of 1.5 mg• kg-1. day-1 to twelve patients over a four week period. Blood gases, ventilation (VE), oxygen consumption (VO₂), carbon dioxide production (VCO₂) and haematocrit were measured every week. There was a slight but significant reduction in haematocrit (-- 3.5 %). Pao₂, and all the other measured parameters (VE, Paco₂, pH, VO₂ Vco₂,) remained constant. The reduction in haematocrit was not therefore due to an increase in diurnal Pao₂, but is perhaps due to the improvement in pulmonary ventilation during sleep. | es_ES |
dc.language.iso | fr | es_ES |
dc.publisher | Bull. Eur. Physiopathol. Respir. | es_ES |
dc.subject | ALMITRINE | es_ES |
dc.subject | ALTURA | es_ES |
dc.subject | ESTIMULACIÓN RESPIRATORIA | es_ES |
dc.title | Étude en double insu de l'effect de l'almitrine sur les malades porteurs de polyglobulie pathologique d'altitude | es_ES |
dc.type | Article | es_ES |