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dc.contributor.authorVargas, Marco
dc.contributor.authorVargas, Enrique
dc.contributor.authorJulian, Colleen Glyde
dc.contributor.authorArmaza, J Fernando
dc.contributor.authorRodriguez, Armando
dc.contributor.authorTellez, Wilma
dc.contributor.authorNiermeyer, Susan
dc.contributor.authorWilson, Megan
dc.contributor.authorParra, Esteban
dc.contributor.authorShriver, Mark
dc.contributor.authorMoore, Lorna G
dc.date.accessioned2016-10-21T18:13:37Z
dc.date.available2016-10-21T18:13:37Z
dc.date.issued2007-07-02
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/8540
dc.description.abstractHigh altitude decreases birth weight, but this effect is diminished in long vs. short-resident, high-altitude populations. We asked whether women from long vs. short-resident, high-altitude populations had higher arterial oxygenation levels by comparing 42 Andean and 26 European residents of La Paz, Bolivia (3,600 m), serially during pregnancy (weeks 20, 30, and 36) and again 4 mo postpartum. Pregnancy raised hypoxic ventilatory sensitivity threefold, resting ventilation (VE), and arterial O2 saturation (Sao2) in both groups. Ancestry, as identified using 81 genetic markers, correlated with respiratory pattern, such that greater Andean ancestry was associated with higher respiratory frequency and lower tidal volume. Pregnancy increased total blood and plasma volume 40% in both groups without changing red blood cell mass relative to body weight; hence, hemoglobin fell. The hemoglobin decline was compensated for by the rise in VE and SaO2 with the result that arterial O2 content (Cao2) was maintained near nonpregnant levels in both groups. Birth weights were similar for all Andean and European babies, but after adjusting for variation in gestational age, maternal height and parity, Andeans weighed 209 g more than Europeans. Babies with heavier birth weights and greater ponderal indices were born to Andean women with higher VE during pregnancy. We concluded that while maternal VE and arterial oxygenation were important, some factor other than higher CaO2 was responsible for protecting Andeans from altitude-associated reductions in fetal growth.es_ES
dc.language.isoenes_ES
dc.publisherAm J Physiol Regul Integr Comp Physioles_ES
dc.subjectHipoxiaes_ES
dc.subjectCrecimiento fetales_ES
dc.subjectVentilaciones_ES
dc.subjectPeso al naceres_ES
dc.titleDeterminants of blood oxygenation during pregnancy in Andean and Europeas residents of high altitudees_ES
dc.typeArticlees_ES


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