• A genomewide admixture mapping panel for hispanic/latino populations 

      Xianyun, Mao; Bigham, Abigail W; Mei, Rui; Gutiérrez, Gerardo; Weiss, Ken M; Brutsaert, Tom D; León-Velarde, Fabiola; Moore, Lorna G; Vargas, Enrique; McKeigue, Paul M; Shriver, Mark D; Parra, Esteban J (The American Journal of Human Genetics, 2007-06)
      Admixture mapping (AM) is a promising method for the identification of genetic risk factors for complex traits and diseases showing prevalence differences among populations. Efficient application of this method requires the ...
    • Andean and Tibetan patterns of adaptation to high altitude 

      Bigham, Abigail W; Wilson, Megan J; Julian, Colleen Glyde; Kiyamu, Melisa; Vargas, Enrique; León-Velarde, Fabiola; Rivera-Chira, María; Rodríguez, Carmelo; Browne, Vaughn A.; Parra, Esteban; Brutsaert, Tom D; Moore, Lorna G; Shriver, Mark D (American Journal of Human Biology, 2013-01-24)
      Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
    • Consensus statement on chronic and subacute high altitude diseases 

      León-Velarde, Fabiola; Maggiorini, Marco; Reeves, John T; Aldashev, Almaz; Asmus, Ingrid; Bernardi, Luciano; Ge, Ri-Li; Hackett, Peter; Kobayashi, Toshio; Moore, Lorna G; Peñaloza, Dante; Richalet, Jean-Paul; Roach, Robert; Wu, Tianyi; Vargas, Enrique; Zubieta-Castillo, Gustavo; Zubieta-Calleja, Gustavo (High Altitude Medicine & Biology, 2005)
      ABSTRACT. This is an international consensus statement of an ad hoc committee formed by the In ternational Society for Mountain Medicine (ISMM) at the VI World Congress on Mountain Med icine and High Altitude Physiology ...
    • Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas 

      Galanter, Joshua Mark; Fernández-López, Juan Carlos; Gignoux, Christopher R.; Barnholtz-Sloan, Jill; Fernández-Rozadilla, Ceres; Via, Marc; Hidalgo-Miranda, Alfredo; Contreras, Alejandra V; Uribe Figueroa, Laura; Raska, Paola; Jiménez-Sánchez, Gerardo; Silva Zolezzi, Irma; Torres, María; Ruiz Ponte, Clara; Ruiz, Yarimar; Salas, Antonio; Nguyen, Elizabeth; Eng, Celeste; Borjas, Lisbeth; Zabala, William; Barreto, Guillermo; Rondón González, Fernando; Ibarra, Adriana; Taboada, Patricia; Porras, Liliana; Moreno, Fabián; Bigham, Abigail; Gutiérrez, Gerardo; Brutsaert, Tom; León-Velarde, Fabiola; Moore, Lorna G; Vargas, Enrique; Cruz, Miguel; Escobedo, Jorge; Rodríguez-Santana, José; Rodríguez-Cintrón, William; Chapela, Rocio; Ford, Jean G; Bustamante, Carlos; Seminara, Daniela; Shriver, Mark; Ziv, Elad; Gonzalez Burchard, Esteban; Haile, Robert; Parra, Esteban; Carracedo, Ángel (PLOS Genetics, 2012-03-08)
      Abstract. Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions ...
    • European genetic admixture predicts decrement in aerobic performance at 4338 meters in peruvian quechua 

      Brutsaert, Tom; Parra, Esteban; Shriver, Mark; Gamboa, Alfredo; Palacios, José-Antonio; Rivera, María; Rodríguez, Ivette; León-Velarde, Fabiola (High Altitude Medicine & Biology, 2003-02-19)
      Quechua natives of the highland Andes may be genetically adapted to high altitude and thus able to resist decrements in maximal O2 consumption in hypoxia (DVO2max). This evolutionary hypothesis was tested via the repeated ...