Listar Producción científica por autor "Julian, Colleen Glyde"
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Andean and Tibetan patterns of adaptation to high altitude
Bigham, Abigail W; Wilson, Megan J; Julian, Colleen Glyde; Kiyamu, Melisa; Vargas, Enrique; León-Velarde, Fabiola; Rivera-Chira, María; Rodríguez, Carmelo; Browne, Vaughn A.; Parra, Esteban; Brutsaert, Tom D; Moore, Lorna G; Shriver, Mark D (American Journal of Human Biology, 2013-01-24)Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ... -
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
Julian, Colleen Glyde; Wilson, Megan J; López, Miriam; Yamashiro, Henry; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail W; Shriver, Mark D; Rodríguez, Carmelo; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2009-02-20)Abstract. The effect of high altitude on reducing birth weight is markedly less in populations of high- (e.g., Andeans) relative to low-altitude origin (e.g., Europeans). Uterine artery (UA) blood flow is greater ... -
Determinants of blood oxygenation during pregnancy in Andean and Europeas residents of high altitude
Vargas, Marco; Vargas, Enrique; Julian, Colleen Glyde; Armaza, J Fernando; Rodríguez, Armando; Téllez, Wilma; Niermeyer, Susan; Wilson, Megan; Parra, Esteban; Shriver, Mark; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2007-07-02)High altitude decreases birth weight, but this effect is diminished in long vs. short-resident, high-altitude populations. We asked whether women from long vs. short-resident, high-altitude populations had higher arterial ... -
Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A.; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reprod Sci., 2010-09)Abstract. Objective: This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors contribute ... -
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A; Rodríguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reproductive Sciences, 2011)Abstract. Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ... -
Graduated effects of high-altitude hypoxia and highland ancestry on birth size
Soria, Rudy; Julian, Colleen Glyde; Vargas, Enrique; Moore, Lorna G; Giussani, Dino A (Pediatric Research, 2013-10-02)Background: We present a cohort of ca. 25,000 birth records from Bolivia of men and women who are currently adults. We used this cohort to test the hypothesis that high altitude reduces birth weight and that highland ... -
Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents
Wilson, Megan J; López, Miriam; Vargas, Marco; Julian, Colleen Glyde; Téllez, Wilma; Rodríguez, Armando; Bigham, Abigail; Armaza, J Fernando; Niermeyer, Susan; Shriver, Mark; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2007)Multigenerational (Andean) compared with shorter-term (European) high-altitude residents exhibit less hypoxia-associated reductions in birth weight. Because differences in arterial O2 content are not responsible, we ... -
High-altitude ancestry protects against hypoxia-associated reductions in fetal growth
Julian, Colleen Glyde; Vargas, Enrique; Armaza, J Fernando; Wilson, Megan J; Niermeyer, Susan; Moore, Lorna G (Archives of Disease in Childhood-Fetal and Neonatal, 2007-02-28)Objective: The chronic hypoxia of high-altitude (>2500 m) residence has been shown to decrease birth weight in all populations studied to date. However, multigenerational high-altitude populations appear protected relative ... -
High-altitude ancestry protects against IUGR and reductions in birth weight associated with high altitude and preeclampsia
Julian, Colleen Glyde; Vargas, Enrique; MacCannell, Wendy; Armaza, Fernando; Moore, Lorna G (High Altitude Medicine & Biology, 2005-02-22)Background. Observations consistently demonstrate diminished birth weight [BW] with ascending altitude; however population comparisons reveal the extent of BW reduction depends, in part, upon high-altitude ancestry. ... -
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
Browne, Vaughn A; Toledo-Jaldín, Lilian; Dávila, R Daniela; López, Luis P; Yamashiro, Henry; Cioffi-Ragan, Darleen; Julian, Colleen Glyde; Wilson, Megan J; Bigham, Abigail W; Shriver, Mark D; Honigman, Benjamín; Vargas, Enrique; Roach, Robert; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2011)The reduction in infant birth weight and increased frequency of preeclampsia (PE) in high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ... -
Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity
Charles, Shelton M; Julian, Colleen Glyde; Vargas, Enrique; Moore, Lorna G (J Clin Endocrinol Metab, 2014-08)Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the result of reduced aromatase activity. Objective: We asked whether the chronic hypoxia of residence at high altitude in the ... -
Inhibition of peroxisome proliferator gamma (PPARɣ) : a potential link between chronic maternal hypoxia and impaired fetal growth
Julian, Colleen Glyde; Yang, Ivana; Vargas, Enrique; Pedersen, Brent S; Moore, Lorna G; Schwartz, David (Journal of Women's Health, 2013)Background and Objective: Chronic maternal hypoxia impairs fetal growth and increases the incidence of intrauterine growth restriction (IUGR). To identify the mechanisms underlying these hypoxia-related effects, we evaluated ... -
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
Julian, Colleen Glyde; Yang, Ivana V; Browne, Vaughn A.; Vargas, Enrique; Rodríguez, Carmelo; Pedersen, Brent S; Moore, Lorna G; Schwartz, David A (FASEB Journal, 2014)Abstract. Chronic exposure to hypoxia raises the risk of pregnancy disorders characterized by maternal vascular dysfunction and diminished fetal growth. In an effort to identify novel pathways for these hypoxiarelated ... -
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
Julian, Colleen Glyde; Hageman, Jennifer L; Wilson, Megan J; Vargas, Enrique; Moore, Lorna G (American Journal of Human Biology, 2011-04-27)Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ... -
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
Bigham, Abigail W; Julian, Colleen Glyde; Wilson, Megan J; Vargas, Enrique; Browne, Vaughn A.; Shriver, Mark D; Moore, Lorna G (Physiol Genomics, 2014-07-14)Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ... -
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction
Julian, Colleen Glyde; Gonzales, Marcelino; Rodríguez, Armando; Bellido, Diva; Salinas Salmón, Carlos; Ladenburger, Anne; Reardon, Lindsay; Vargas, Enrique; Moore, Lorna G (Am J Physiol Heart Circ Physiol, 2015-04-27)Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol 309: H565–H573, 2015. First published June 19, 2015; doi:10.1152/a ... -
Perinatal origins of chronic mountain sickness : the role of perinatal hypoxia in the development of CMS
Vargas, Enrique; Julian, Colleen Glyde; Salinas Salmón, Carlos E; Dávila, Daniela; Rodríguez, Armando; Gonzales, Marcelino; Moore, Lorna G (Meeting VII Congress World Medicine and Physiology High Altitude, 2011) -
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
Julian, Colleen Glyde; Vargas, Enrique; Browne, Vaughn A.; Wilson, Megan J; Bigham, Abigail W; Rodríguez, Carmelo; McCord, Joe M; Moore, Lorna G (The Journal of Maternal-Fetal and Neonatal Medicine, 2012)Oxidative stress has been implicated in the uteroplacental ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high (>2500 m) vs low altitude. Since Andeans ... -
Reduced endothelin-1 (ET-1) and elevated nitric oxide metabolites (NOX) across pregnancy among andean vs. european women at high (3100-3600 m) altitude
Julian, Colleen Glyde; Wilson, Megan; Vargas, Enrique; Vargas, Marco; López, Miriam; Niermeyer, Susan; Moore, Lorna G (High Altitude Medicine & Biology, 2005-02-22)Background. A consistent reduction in infant birth weight occurs with ascending altitude; however multigenerational high-altitude residents [Andeans] demonstrate a degree of protection from altitude-associated IUGR ... -
Role of cytokines in altitude-associated preeclampsia
Dávila, R Daniela; Julian, Colleen Glyde; Browne, Vaughn A.; Toledo-Jaldín, Lillian; Wilson, Megan J; Rodríguez, Armando; Vargas, Enrique; Moore, Lorna G (Pregnancy Hypertens, 2012-01)Abstract. Background: Preeclampsia (PE) is more common at high than low altitude and contributes to the altitude-related decline in birth weight. Since inflammatory markers are implicated in PE, we asked if such markers ...