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Andean compared with european women are protected from altitude-associated intrauterine growth restriction (IUGR)
(s.n., 2003)
Abstract.
Babies born at high altitude to long-term high-altitude residents weigh more than those of recent migrants from low altitude. Objective: We asked whether a gradient exists such that persons of Andean ancestry ...
Human physiological adaptation to pregnancy : inter- and intrspecific perspectives
(American Journal of Human Biology, 2003)
Abstract.
Reproductive success requires successful maternal physiological adaptation to pregnancy. An interspecific perspective reveals that the human species has modified features of our haplorhine heritage affecting ...
Andean women have greater uterine artery (UTA) enlargement during pregnancy than european residents of 3600 m.
([s.n.], 2003)
Abstract.
Babies weigh less at high altitude but multi-generational high-altitude residents are protected from this birth weight decline (Moore HAMB 2001). Objective: We asked if higher arterial oxygenation and/or blood ...
Inhibition of peroxisome proliferator gamma (PPARɣ) : a potential link between chronic maternal hypoxia and impaired fetal growth
(Journal of Women's Health, 2013)
Background and Objective: Chronic maternal hypoxia impairs
fetal growth and increases the incidence of intrauterine growth restriction (IUGR). To identify the mechanisms underlying these hypoxia-related effects, we evaluated ...
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas
(PLOS Genetics, 2012-03-08)
Abstract.
Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors.
Complex historical factors have resulted in varying proportions of ancestral contributions ...
Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitutde (2013 Grover Conference series)
(Pulm Circ, 2015-03)
Abstract.
Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident
groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness
(CMS). We hypothesized ...
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity
(J Clin Endocrinol Metab, 2014-08)
Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the
result of reduced aromatase activity.
Objective: We asked whether the chronic hypoxia of residence at high altitude in the ...