Now showing items 1-10 of 10

  • Does chronic mountain sickness (CMS) have perinatal origins? 

    Moore, Lorna G; Niermeyer, Susan; Vargas, Enrique (Respiratory Physiology & Neurobiology, 2007-06-29)
    A b s t r a c t Chronic mountain sickness (CMS) occurs in 10% of male high-altitude residents. It is characterized by hypoventilation and hypoxemia but its underlying cause remains unknown. We hypothesized that CMS' ...
  • High-altitude ancestry protects against IUGR and reductions in birth weight associated with high altitude and preeclampsia 

    Julian, Colleen Glyde; Vargas, Enrique; MacCannell, Wendy; Armaza, Fernando; Moore, Lorna G (High Altitude Medicine & Biology, 2005-02-22)
    Background: Observations consistently demonstrate diminished birth weight [BW] with ascending altitude; however population comparisons reveal the extent of BW reduction depends, in part, upon high-altitude ancestry. O ...
  • Increased incidence of preeclampsia lowers birth weight and increases intrauterine mortality at high altitude 

    Armaza, Fernando; Vargas, Enrique; Bohrt, Roberto; Moore, Lorna G (High Altitude Medicine & Biology, 2001)
    Objective: Residence at high altitude decreases birth weight due to intrauterine growth restriction (IUGR) and increases the incidence of preeclampsia in Colorado.We asked whether preeclampsia is more common at high ...
  • Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia 

    Keyes, LE; Armaza, Fernando; Niermeyer, Susan; Vargas, Enrique; Young, David A; Moore, Lorna G (PEDIATRIC RESEARCH, 2003-02-18)
    Infant mortality and stillbirth rates in Bolivia are high and birth weights are low compared with other South American countries. Most Bolivians live at altitudes of 2500 m or higher. We sought to determine the impact of ...
  • Maternal and fetoplacental hypoxia do not alter circulating angiogenec growth effectors during human pregnancy 

    Zamudio, Stacy; Borges, Marcus; Echalar, Lourdes; Kovalenko, Olga; Vargas, Enrique; Torricos, Tatiana; Al Khan, Abdulla; Alvarez, Manuel; Illsley, Nicholas P (Biol Reprod., 2014-02-27)
    ABSTRACT One causal model of preeclampsia (PE) postulates that placental hypoxia alters the production of angiogenic growth effectors (AGEs), causing an imbalance leading to maternal endothelial cell dysfunction. We ...
  • Nuevos mecanismos para hipertensión arterial pulmonar en la altura 

    Salinas Salmón, Carlos (COLEGIO MEDICO DE BOLIVIA, 2016-02)
    RESUMEN Durante la última década el alcance de la investigación en la altura se ha ampliado considerablemente. Dos importantes observaciones han generado este avance; Primero, el hecho de que el edema pulmonar agudo de ...
  • Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension 

    Sartori, Claudio; Jayet, Pierre-Yves; Thalmann, Sebastien; Stuber, Thomas; Hutter, Damian; Salinas Salmón, Carlos E; Cucchia, Celine; Rodriguez, Armando; Riveros, Loyola; Spielvogel, Hilde; Allemann, Yves; Villena, Mercedes; Scherrer, Urs (High Altitude Medicine & Biology, 2005-02-22)
    Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors that cause maternal endothelial dysfunction. These factors ...
  • Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia 

    Jayet, Pierre-Yves; Rimoldi, Stefano F; Stuber, Thomas; Salinas Salmón, Carlos E; Hutter, Damian; Rexhaj, Emrush; Thalmann, Sébastien; Schwab, Marcos; Turini, Pierre; Sartori-Cucchia, Céline; Nicod, Pascal; Villena, Mercedes; Allemann, Yves; Scherrer, Urs; Sartori, Claudio (Circulation, 2010-07-19)
    Background—Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the ...
  • Response to letters regarding article, "Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia" 

    Rimoldi, Stefano F; Jayet, Pierre-Yves; Rexhaj, Emrush; Thalmann, Sébastien; Schwab, Marcos; Turini, Pierre; Sartori-Cucchia, Céline; Nicod, Pascal; Scherrer, Urs; Sartori, Claudio; Hutter, Damian; Stuber, Thomas; Allemann, Yves; Salinas Salmón, Carlos E; Villena, Mercedes (Circulation, 2011)
    We thank Lazdam et al and Yuan et al for their interesting comments on our study.1 Lazdam et al point out that in our study, birth weight in offspring of mothers with preeclampsia was significantly lower than in controls, ...
  • Unique DNA methylation patterns in offspring of hypertensive 

    Julian, Colleen Glyde; Pedersen, Brent S; Salinas Salmón, Carlos; Yang, Ivana V; Gonzales, Marcelino; Vargas, Enrique; Moore, Lorna G; Schwartz, David A (2015)
    Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications of pregnancy ...