Now showing items 1-8 of 8

  • Determinants of blood oxygenation during pregnancy in Andean and Europeas residents of high altitude 

    Vargas, Marco; Vargas, Enrique; Julian, Colleen Glyde; Armaza, J Fernando; Rodriguez, Armando; Tellez, Wilma; Niermeyer, Susan; Wilson, Megan; Parra, Esteban; Shriver, Mark; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2007-07-02)
    High altitude decreases birth weight, but this effect is diminished in long vs. short-resident, high-altitude populations. We asked whether women from long vs. short-resident, high-altitude populations had higher arterial ...
  • Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry? 

    Dávila, R Daniela; Julian, Colleen Glyde; Wilson, Megan J; Browne, Vaughn A.; Rodriguez, Carmelo; Bigham, Abigail W; Shriver, Mark D; Vargas, Enrique; Moore, Lorna G (Reprod Sci., 2010-09)
    A b s t r a c t Objective—This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors ...
  • Does chronic mountain sickness (CMS) have perinatal origins? 

    Moore, Lorna G; Niermeyer, Susan; Vargas, Enrique (Respiratory Physiology & Neurobiology, 2007-06-29)
    A b s t r a c t Chronic mountain sickness (CMS) occurs in 10% of male high-altitude residents. It is characterized by hypoventilation and hypoxemia but its underlying cause remains unknown. We hypothesized that CMS' ...
  • Evidence that parent-of-origin affects birth-weight reductions at high altitude 

    Bennett, Adam; Sain, Stephen R; Vargas, Enrique; Moore, Lorna G (American Journal of Human Biology, 2008-02-19)
    ABSTRACT Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high-altitude populations are relatively protected from this birth-weight decline, ...
  • Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents 

    Wilson, Megan J; Lopez, Miriam; Vargas, Marco; Julian, Colleen Glyde; Tellez, Wilma; Rodriguez, Armando; Bigham, Abigail; Armaza, J Fernando; Niermeyer, Susan; Shriver, Mark; Vargas, Enrique; Moore, Lorna G (Am J Physiol Regul Integr Comp Physiol, 2007)
    Multigenerational (Andean) compared with shorter-term (European) high-altitude residents exhibit less hypoxia-associated reductions in birth weight. Because differences in arterial O2 content are not responsible, we ...
  • High-altitude ancestry protects against IUGR and reductions in birth weight associated with high altitude and preeclampsia 

    Julian, Colleen Glyde; Vargas, Enrique; MacCannell, Wendy; Armaza, Fernando; Moore, Lorna G (High Altitude Medicine & Biology, 2005-02-22)
    Background: Observations consistently demonstrate diminished birth weight [BW] with ascending altitude; however population comparisons reveal the extent of BW reduction depends, in part, upon high-altitude ancestry. O ...
  • Role of cytokines in altitude-associated preeclampsia 

    Dávila, R Daniela; Julian, Colleen Glyde; Browne, Vaughn A.; Toledo-Jaldín, Lillian; Wilson, Megan J; Rodriguez, Armando; Vargas, Enrique; Moore, Lorna G (Pregnancy Hypertens, 2012-01)
    A b s t r a c t Background: Preeclampsia (PE) is more common at high than low altitude and contributes to the altitude-related decline in birth weight. Since inflammatory markers are implicated in PE, we asked if such ...
  • Variación en hemoglobina materna y peso al nacer en la altura 

    Haas, Jere D; Small, Daniel; Beard, John L; Hurtado Gomez, Luis (Instituto Boliviano de Biología de Altura, 1983)
    Resumen. El peso reducido de los recién nacidos en la altura ha sido frecuentemente mencionado en la literatura médico-científica. A pesar de ello, pocos esfuerzos se han hecho para determinar las causas de esta variación ...