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dc.contributor.authorBrenière, Simone Frédérique
dc.contributor.authorYaksic, Nina
dc.contributor.authorTelleria, Jenny
dc.contributor.authorBosseno, Marie France
dc.contributor.authorNoireau, François
dc.contributor.authorWincker, Patrick
dc.contributor.authorSanchez, Daniel
dc.date.accessioned2017-11-21T14:29:24Z
dc.date.available2017-11-21T14:29:24Z
dc.date.issued1997
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/13645
dc.description.abstractA field study of the immune response to the shed acute phase antigen (SAPA) of Trypanosoma cruzi was carried out in the locality of Mizque, Cochabamba department, Bolivia. Schoolchildren (266), with an average of 8.6 ± 3.6 years, were surveyed for parasitological and serological diagnosis, as well as antibodies directed against SAPA using the corresponding recombinant protein in ELISA. The antibodies against SAPA were shown in 82% of patients presenting positive serological diagnosis (IgG specific antibodies). The positive and negative predictive values were 0.88. Antibodies anti-SAPA were shown in 80.8% of the chagasic patients in the initial stage of the infection (positive IgM serology and/or positive buffy coat (BC) test) and in 81.4% of the patients in the indeterminate stage of the infection (positive IgG serology with negative BC and IgM tests). These results show that the anti-SAPA response is not only present during the initial stage of the infection (few months) but extends some years after infection.es_ES
dc.language.isoenes_ES
dc.publisherMem. Inst. Oswaldo Cruzes_ES
dc.subjectTrypanosoma cruzies_ES
dc.subjectArrojar antígeno de fase agudaes_ES
dc.subjectRespuesta humorales_ES
dc.subjectDiagnóstico serológicoes_ES
dc.titleImmune response to Trypanosoma cruzi shed acute phase antigen in children from an endemic area for Chagas'disease in Boliviaes_ES
dc.typeArticlees_ES


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