Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)

dc.contributor.author	Waechter, Anne-Isabelle
dc.contributor.author	Cavé, André
dc.contributor.author	Hocquemiller, Reynald
dc.contributor.author	Bories, Christian
dc.contributor.author	Muñoz, Victoria
dc.contributor.author	Fournet, Alain
dc.date.accessioned	2017-10-30T15:21:28Z
dc.date.available	2017-10-30T15:21:28Z
dc.date.issued	1999
dc.identifier.uri	http://repositorio.umsa.bo/xmlui/handle/123456789/13144
dc.description.abstract	On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of Unonopsis buchtienii, the alkaloids and sterols isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against Leishmania major and L. donovani (IC₁₀₀ = 3.12 µg/mL). On the other hand, O-methylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against Trypanosoma brucei with an IC₁₀₀ of 6.25 µg/mL. The highest cytotoxic activities were found with the petroleum ether extracts without alkaloids and with all alkaloids isolated (IC₅₀ < 9µg/mL for Vero cell line).	es_ES
dc.language.iso	en	es_ES
dc.publisher	PHYTOTHERAPY RESERARCH	es_ES
dc.subject	LEISHMANIASIS	es_ES
dc.subject	UNONOPSIS BUCHTIENII	es_ES
dc.subject	ANNONACEAE	es_ES
dc.title	Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)	es_ES
dc.type	Article	es_ES