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dc.contributor.authorFournet, Alain
dc.contributor.authorAngelo, Alcira
dc.contributor.authorMuñoz, Victoria
dc.contributor.authorRoblot, François
dc.contributor.authorHocquemiller, Reynald
dc.contributor.authorCavé, André
dc.date.accessioned2017-09-15T14:36:22Z
dc.date.available2017-09-15T14:36:22Z
dc.date.issued1992
dc.identifier.urihttp://repositorio.umsa.bo/xmlui/handle/123456789/12470
dc.description.abstractThe stem barks of Pera benensis are employed by the Chimane Indians in the Bolivian Amazonia as treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. The chloroform extracts containing quinones were found active against the promastigote forms of Leishmania and the epimastigote forms of Trypanosoma cruzi at 10 ug ml-1. The activity guided fractionation of the extract by chromatography afforded active compounds. Their structures were elucidated, by spectral and chemical studies, as known naphthoquinones, plumbagin, 3,3’ - biplumbagin, 8-8’ –biplumbagin, and triterpene, lupeol. The activity in vitro of each compound was evaluated against 5 strains of Leishmania (promastigote), 6 strains of Trypasonoma cruzi (epimastigote) and the intracellular form (amastigote) of Leishmania amazonensis. The baseline drugs used were Glucantime and pentamidine (Leishmania spp.), nifurtimox and benznidazole (T. cruzi). Plumbagin was the most active compound in vitro. This study has demonstrated that Pera benensis, a medicinal plant used in folk medicine, is an efficient treatmen of cutaneous leismaniasis.es_ES
dc.language.isoenes_ES
dc.publisherJournal of Ethnopharmacologyes_ES
dc.subjectINDIOS CHIMANESes_ES
dc.subjectMEDICINA POPULARes_ES
dc.subjectLEISHMANIASIS CUTÁNEAes_ES
dc.subjectPERA BENENSISes_ES
dc.subjectEUPHORBIACEAEes_ES
dc.subjectLEISHMANIA SP.es_ES
dc.subjectTRYPANOSOMA CRUZIes_ES
dc.subjectNAFTOQUINONASes_ES
dc.titleBiological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasises_ES
dc.typeArticlees_ES


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