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Excessive polycythemia occurs in young high-altitude (3600 M) residents in the absence of lung disease
dc.contributor.author | Vargas, Enrique | |
dc.contributor.author | Villena, Mercedes | |
dc.contributor.author | Salinas Salmón, Carlos E | |
dc.contributor.author | Rodríguez, Armando | |
dc.contributor.author | Spielvogel, Hilde | |
dc.contributor.author | Téllez, Wilma | |
dc.contributor.author | Bellido, Diva | |
dc.date.accessioned | 2017-03-03T16:14:50Z | |
dc.date.available | 2017-03-03T16:14:50Z | |
dc.date.issued | 2002-04-18 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/9775 | |
dc.description.abstract | Objective: Chronic Mountain Sickness occurs in , 8% of the La Paz population. We asked whether its primary diagnostic sign, excessive polycythemia (EP), occurred in youngeraged persons without lung disease. Methods: In the 6200 persons referred to IBBA over the past 5 yrs, male hemoglobin (hgb) averages 17.5 gm/dL; we considered EP as values above this mean. From this population, we selected 26 younger- and 31 older-aged persons with EP (YEP, age = 20+1 yr; OEP, age = 36+1 yr) and 30 younger controls (C, age = 22+1 yr). Results: Height was similar but OEP weighed more (68.8+1.1 kg) than C or YEP (60.7+1.4, 63.7+1.4 kg, both p,<05 vs C). YEP and OEP had lower PaO2 and SaO2 than C, but PaCO2 was higher only in OEP. Higher hgb was associated with lower PaO2 (R2 = 0.55) and higher PaCO2 (R2 = 0.36) in all subjects. The increase in ventilation following 3 breaths of 10% O2 in N2 was reduced in YEP and OEP vs C. Forced vital capacity (FVC) and the FEV1/FVC ratio were similar in YEP and C but reduced in OEP. Diffusing capacity for CO was lower in YEP and OEP vs C but similar when controlled for hgb. Conclusion: EP occurs in younger-aged men in the absence of apparent lung disease but in the presence of a blunted ventilatory response to hypoxia and a suggestion of hypoventilation. (Supported by the French Cooperation and Universidad Mayor de San Andrés, La Paz, BO). | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | High Altitude Medicine & Biology | es_ES |
dc.subject | POLICITEMIA EXCESIVA | es_ES |
dc.subject | AUSENCIA ENFERMEDAD PULMONAR | es_ES |
dc.subject | GRAN ALTURA | es_ES |
dc.title | Excessive polycythemia occurs in young high-altitude (3600 M) residents in the absence of lung disease | es_ES |
dc.type | Article | es_ES |