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Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
(Reprod Sci., 2010-09)
Abstract.
Objective: This prospective study was designed to determine whether variation in angiogenic
(placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1])
factors contribute ...
Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia
(Circulation, 2010-07-19)
Background—Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the ...
Perinatal origins of chronic mountain sickness : the role of perinatal hypoxia in the development of CMS
(Meeting VII Congress World Medicine and Physiology High Altitude, 2011)
Hypoglycemia and the origin of hypoxia-induced reduction in human fetal growth
(PLOS One, 2010-01)
Abtract.
Background: The most well known reproductive consequence of residence at high altitude (HA .2700 m) is reduction in
fetal growth. Reduced fetoplacental oxygenation is an underlying cause of pregnancy pathologies, ...
The role of perinatal hypoxia in the development of preclinical CMS
(High Altitude Medicine & Biology, 2010-08-08)
Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth factors : the emperor's got no clothes?
(The Journal of Clinical Endocrinology & Metabolism, 2010)
ABSTRACT.
Context: Placental hypoxia alters production of angiogenic growth factors (AGFs), thought to be
causally involved in the development of the pregnancy-specific disease preeclampsia (PE).
Consistent with this, ...
Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness
(CHEST, 2010-02)
Background: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause ...
mtDNA and y-chromosome diversity in aymaras and quechuas from Bolivia : different stories and special genetic traits of the andean altiplano populations
(American Journal of Physical Anthroplogy, 2011-04-05)
Abstract.
Two Bolivian samples belonging to the
two main Andean linguistic groups (Aymaras and Quechuas) were studied for mtDNA and Y-chromosome uniparental markers to evaluate sex-specific differences and
give new ...
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
(Am J Physiol Regul Integr Comp Physiol, 2011)
The reduction in
infant birth weight and increased frequency of preeclampsia (PE) in
high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...
Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight
(American Journal of Human Biology, 2011-04-27)
Objective. Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important
determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability ...