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Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
(Am J Physiol Regul Integr Comp Physiol, 2009-02-20)
Abstract.
The effect of high altitude on reducing birth weight is markedly less in
populations of high- (e.g., Andeans) relative to low-altitude origin
(e.g., Europeans). Uterine artery (UA) blood flow is greater ...
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
(Reproductive Sciences, 2011)
Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...
Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
(The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
Oxidative stress has been implicated in the uteroplacental
ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high
(>2500 m) vs low altitude. Since Andeans ...