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Increased incidence of preeclampsia lowers birth weight and increases intrauterine mortality at high altitude
(High Altitude Medicine & Biology, 2001)
Does chronic mountain sickness (CMS) have perinatal origins?
(Respiratory Physiology & Neurobiology, 2007-06-29)
Abstract.
Chronic mountain sickness (CMS) occurs in 10% of male high-altitude residents. It is characterized by hypoventilation and hypoxemia but its underlying cause remains unknown. We hypothesized that CMS' origins ...
Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia
(PEDIATRIC RESEARCH, 2003-02-18)
Abstract.
Infant mortality and stillbirth rates in Bolivia are high and birth weights are low compared with other South American countries. Most Bolivians live at altitudes of 2500 m or higher. We sought to determine the ...
High-altitude ancestry protects against IUGR and reductions in birth weight associated with high altitude and preeclampsia
(High Altitude Medicine & Biology, 2005-02-22)
Background.
Observations consistently demonstrate diminished birth weight [BW] with ascending altitude;
however population comparisons reveal the extent of BW
reduction depends, in part, upon high-altitude ancestry.
...
Offspring of preeclamptic mothers are predisposed to hypoxic pulmonary hypertension
(High Altitude Medicine & Biology, 2005-02-22)
Adverse events in utero may predispose to cardiovascular disease in adulthood. In preeclampsia, the diseased placenta releases circulating vasculotoxic factors
that cause maternal endothelial dysfunction. These factors ...
An evolutionary model for identifying genetic adaptation to high altitude
(Adv Exp Med Biol., 2006)
Abstract
Coordinated maternal/fetal responses to pregnancy are required to ensure continuous O2 delivery to the developing organism. Mammals employ distinctive reproductive strategies that afford their young an improved ...
Pulmonary hypertension in high-altitude dwellers : novel mechanisms, unsuspected predisposing factors
(Adv Exp Med Biol., 2006)
Abstract
Studies of high-altitude populations, and in particular of maladapted subgroups, may provide important insight into underlying mechanisms involved in the pathogenesis of hypoxemia-related disease states in general. ...